{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:09:20Z","timestamp":1791356960231,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal\u2010derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight sulfonamides, nine fluoroquinolones, four tetracyclines, and five macrolides) were screened in 88 meat samples (cattle muscles and sheep muscles, kidneys, and livers) obtained from southern Xinjiang. The antibiotics were screened via the clean\u2010up step based on solid\u2010phase extraction and determined through ultraperformance liquid chromatography\u2013tandem mass spectrometry. Moreover, their risk to human health was analyzed. Overall, 16 antibiotics were detected with a total detection rate of 95.46%. The percentage of noncompliant samples was 28.41% with an exceedance maximum residue limit of 1.14%. The illegal use rate of the antibiotic norfloxacin was 27.27%. The estimated daily exposure doses of all compounds in adults were &lt;102.218\u00a0ng\/kg\u00a0bw\/day even after applying the worst\u2010case scenario approach. This result demonstrated that the antibiotic residues in the tested samples imposed negligible harm to people's health and had an acceptable level of food safety risk. However, the high detection frequencies found in this work indicated that the risk of antibiotic residues could not be ignored given the cumulative risk of antibiotics, particularly the emergence of bacterial resistance, to the human body. The need for effective strategies and publicity for the judicious use of antibiotics to safeguard residents\u2019 health is immediate.<\/jats:p>","DOI":"10.1002\/fsn3.2568","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T11:29:26Z","timestamp":1631532566000},"page":"6152-6161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China"],"prefix":"10.1002","volume":"9","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/Key Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang Bingtuan Shihezi University Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjiang","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/Key Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang Bingtuan Shihezi University Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/Key Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang Bingtuan Shihezi University Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/Key Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang Bingtuan Shihezi University Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/Key Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang Bingtuan Shihezi University Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2018.04.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.12.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.11.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157\u20107579.1000285"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2019.1395\u20101407"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12185"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"885","article-title":"Sulfonamides determination in chicken meat products from Malaysia","volume":"17","author":"Cheong C. K.","year":"2010","journal-title":"International Food Research Journal"},{"issue":"70","key":"e_1_2_9_9_1","first-page":"193","article-title":"The impact of antibiotics on the gut microbiota as revealed by high throughput DNA sequencing","volume":"13","author":"Cotter P. D.","year":"2012","journal-title":"Discovery Medicine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.4.4.214"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2008.16"},{"key":"e_1_2_9_12_1","volume-title":"Veterinary drug residues in processed meats\u2014potential health risk","author":"Doyle M. E.","year":"2006"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"943","article-title":"Antibiotic residue levels in camel, cattle and sheep tissues using LC\u2010MS\/MS method","volume":"29","author":"El\u2010Ghareeb W. R.","year":"2019","journal-title":"Journal of Animal and Plant Sciences"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013\u201003072"},{"key":"e_1_2_9_15_1","first-page":"77","article-title":"The current situation, problems and countermeasures of Xinjiang mutton sheep industry (in Chinese)","volume":"12","author":"Gan C.","year":"2014","journal-title":"Xinjiang Agricultural Reclamation Economy"},{"key":"e_1_2_9_16_1","volume-title":"Xinjiang Statistical Yearbook","author":"Gao W.","year":"2019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.10520\/EJC180082"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2010.06.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00190\u201012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13765\u2010012\u20102220\u20104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9101479"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2020.103512"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.08.014"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00002\u201011"},{"key":"e_1_2_9_25_1","unstructured":"Ministry of Agriculture of the People's Republic of China. (2002).Maximum residue limits of veterinary drugs in animal food (235 Bulletin). Retrieved fromwww.moa.gov.cn\/gk\/tzgg_1\/gg\/200302\/t20030226_59300.htm"},{"key":"e_1_2_9_26_1","unstructured":"Ministry of Agriculture of the People's Republic of China(2015).2292 Bulletin of the Ministry of Agriculture of the People's Republic of China. Retrieved fromhttp:\/\/www.moa.gov.cn\/nybgb\/2015\/jiuqi\/201712\/t20171219_6103873.htm"},{"key":"e_1_2_9_27_1","unstructured":"Ministry of Agriculture of the People's Republic of China(2019).194 Bulletin of the Ministry of agriculture and rural areas of the People\u2019s Republic of China. Retrieved fromhttp:\/\/www.moa.gov.cn\/nybgb\/2019\/201907\/202001\/t20200103_6334292.htm"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1212874"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.05.035"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.9734\/EJNFS\/2015\/13795"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503141112"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1373.081"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14090970"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2017.04.034"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2020.1751309"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2096\u20103637.2019.13.106"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b00729"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/es1000159"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.02.142"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.2568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:19:15Z","timestamp":1693214355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.2568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/fsn3.2568"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.2568","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"2021-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}