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This retrospective cohort study included all patients with confirmed COVID\u201019 hospitalized between February 20, 2020, and April 20, 2020, at a designated COVID\u201019 hospital, located in Tehran province, Iran. General characteristics, medical history and clinical symptoms were recorded by trained physicians. Blood parameters including complete blood count, creatinine, lactate dehydrogenase, creatine phosphokinase, erythrocyte sedimentation rate, C\u2010reactive protein and vitamin D were tested. This study included 290 hospitalized patients with COVID\u201019 (the mean age [<jats:italic>SD<\/jats:italic>]: 61.6 [16.9], 56.6% males), of whom 142 had vitamin D concentrations less than 20\u00a0ng\/ml, defined as vitamin D deficiency. COVID\u201019 patients with vitamin D deficiency were more likely to die (Crude OR [95% CI]: 2.30 [1.25\u20134.26]), require ICU (2.06 [1.22\u20133.46]) and invasive mechanical ventilation (2.03 [1.04\u20133.93]) based on univariate logistic regression results. Although, after adjusting for potentials confounders such as gender and age, the association between vitamin D and need to invasive mechanical ventilation lost its significance, adjusted values for the risk of death and ICU requirement were still statistically significant. Vitamin D deficiency can be considered as a predictor of poor outcomes and mortality in COVID\u201019 patients. Therefore, checking serum 25 (OH) D on admission and taking vitamin D supplements according to the prophylactic or treatment protocols is recommended for all COVID\u201019 patients.<\/jats:p>","DOI":"10.1002\/fsn3.2591","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T05:20:44Z","timestamp":1632115244000},"page":"6307-6313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The predictive power of serum vitamin D for poor outcomes in COVID\u201019 patients"],"prefix":"10.1002","volume":"9","author":[{"given":"Hoda","family":"Derakhshanian","sequence":"first","affiliation":[{"name":"Department of Biochemistry Genetics and Nutrition School of Medicine Alborz University of Medical Sciences Karaj Iran"},{"name":"Dietary Supplements and Probiotic Research Center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadith","family":"Rastad","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Biology Okanagan Campus University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Zeinali","sequence":"additional","affiliation":[{"name":"Department of Neurology Firoozgar Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Ziaee","sequence":"additional","affiliation":[{"name":"Department of Neurology Firoozgar Hospital Iran University of Medical Sciences Tehran 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Educational and Medical Center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hasani","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-8471","authenticated-orcid":false,"given":"Zahra","family":"Mirzaasgari","sequence":"additional","affiliation":[{"name":"Department of Neurology Firoozgar Hospital Iran University of Medical Sciences Tehran Iran"},{"name":"Shefa Neuroscience Research Center Tehran 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