{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:47:22Z","timestamp":1790232442670,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Okra (<jats:italic>Abelmoschus esculentus<\/jats:italic>) is a traditionally important vegetable herb used to treat numerous illnesses, including diabetes mellitus, in many rural parts of Bangladesh and the South Asian subcontinent. However, the scientific evidence for the aforementioned properties has not been adequately validated. Hence, the aim of this study was to explore the antidiabetic, antilipidemic activity of okra mucilage powder, and to compare its effectiveness with the isolated peel\u2013seed of okra after mucilage extraction in Swiss albino mice. After extraction, both mucilage and peel\u2013seed were made into powder. In addition, crude protein, mineral contents, and in vitro antioxidant activity of mucilage and peel\u2013seed powder were assessed. After acute toxicity test, methanolic extracts of both powders were administered to alloxan\u2010induced diabetic mice for 3\u00a0weeks. Blood glucose levels were assessed weekly. Finally, blood samples were collected on day 21 to estimate blood glucose level, total protein (TP), and lipid profile levels. Okra mucilage powder showed less amount of protein, calcium, magnesium, phosphorus, potassium, sodium, and iron compared with peel\u2013seed powder. In terms of antioxidant activity, the IC50 value and total phenolic content were found higher in okra mucilage powder in contrast to peel\u2013seed powder. However, total flavonoid content was higher in peel\u2013seed powder than mucilage powder. Three\u2010week administration of mucilage and peel\u2013seed suspensions at a dose of 150\u00a0mg\/kg and 200\u00a0mg\/kg significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) reversed the abnormal changes of bodyweights, water consumption, feed consumption, and fasting blood glucose levels of diabetic subjects. Cholesterol, triglycerides, low\u2010density lipoproteins, high\u2010density lipoproteins, and total protein were found to be significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) improved after mucilage and peel\u2013seed treatment. Thus, Okra can be recommended as a potential source of antidiabetic drug candidate for the effective management of diabetes mellitus and its complications.<\/jats:p>","DOI":"10.1002\/fsn3.2641","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T05:57:41Z","timestamp":1635487061000},"page":"6854-6865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of in vitro antioxidant activity of okra mucilage and its antidiabetic and antihyperlipidemic effect in alloxan\u2010induced diabetic mice"],"prefix":"10.1002","volume":"9","author":[{"given":"A.F.M Irfan","family":"Uddin Zim","sequence":"first","affiliation":[{"name":"Department of Applied Food Science and Nutrition Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Khulshi, Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-1395","authenticated-orcid":false,"given":"Jannatara","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Animal Science &amp; Nutrition Faculty of Veterinary Medicine Chattogram Veterinary and Animal Sciences University Khulshi, Chattogram Bangladesh"},{"name":"Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Khulshi, Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Forhad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"},{"name":"Department of Pharmacy State University of Bangladesh Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Altaf","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Applied Food Science and Nutrition Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Khulshi, Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mozibul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Applied Food Science and Nutrition Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Khulshi, Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199000169-00002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020163"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"96","article-title":"Mucilage content of 21 accessions of okra (Abelmoschus spp L.)","volume":"2","author":"Ahiakpa J.","year":"2014","journal-title":"Scientia Agriculturae"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(14)60084-4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20203022"},{"key":"e_1_2_12_7_1","volume-title":"Official methods of analysis","author":"AOAC","year":"2016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.03.014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.06.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12601"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/160980"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"85","article-title":"Effect of okra seed in treatment of hypoglycemia: A research framework using STZ induced rat","volume":"6","author":"Dubey P.","year":"2018","journal-title":"Journal of Medicinal Plants"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.596"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.282"},{"issue":"458","key":"e_1_2_12_16_1","first-page":"2","article-title":"Nutritional quality and health benefits of okra (Abelmoschus esculentus): A review","volume":"6","author":"Gemede H. 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