{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:34:56Z","timestamp":1788885296302,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herbal drugs play an imperative role in healthcare programs in developing countries. Curry leaves have wide medicinal importance and are used to treat various diseases traditionally. The current study was carried out to estimate the extent of mercury toxicity and the potential effect of curry leaves against defined toxicity. The study group comprised 24 rats weighing between 130 and150\u00a0g. Group 1 was kept normal, and group 2 was exposed to mercury at 0.4\u00a0mg\/kg of body weight in the form of mercuric chloride (HgCl<jats:sub>2<\/jats:sub>). The group 3 animals were treated with curry leaves with a dosage of 300\u00a0mg\/kg of body weight. Group 4 was treated with curry leaves along with mercury with a dosage of 300 and 0.4\u00a0mg\/kg consecutively. After 28\u00a0days, the rats were killed. Blood sample of all groups were evaluated separately to determine the results of different parameters. The results show that ALP, AST, ALT, urea, bilirubin, and creatinine increased with mercury application and decreased with curry leaf exposure. SOD, CAT, GPx, and GR of the liver as well as the kidney depleted on mercury exposure whereas they increased with curry leaf application. HDL increased with curry leaf application and decreased with mercury treatment, while LDL, triglyceride, and cholesterol decreased with curry leaves and increased with mercury exposure. Organ index in mercury along with curry leaf application got close to normal.<\/jats:p>","DOI":"10.1002\/fsn3.2683","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T07:29:40Z","timestamp":1639466980000},"page":"499-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the potential of curry leaves on mercury\u2010induced hepatorenal toxicity in an animal model"],"prefix":"10.1002","volume":"10","author":[{"given":"Muhammad","family":"Ijaz","sequence":"first","affiliation":[{"name":"National Institute of Food Science and Technology University of Agriculture Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Arshad","sequence":"additional","affiliation":[{"name":"Quaid\u2010e\u2010Azam Medical College  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ahmad","family":"Awan","sequence":"additional","affiliation":[{"name":"FMU Faisalabad Medical University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rizwan","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Food Sciences University of the Punjab Quid\u2010i\u2010Azam Campus  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-2516","authenticated-orcid":false,"given":"Shinawar Waseem","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Food Sciences University of the Punjab Quid\u2010i\u2010Azam Campus  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Food Sciences University of the Punjab Quid\u2010i\u2010Azam Campus  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shafiq","sequence":"additional","affiliation":[{"name":"Department of Food Sciences University of the Punjab Quid\u2010i\u2010Azam Campus  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Medical Sciences  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-5607","authenticated-orcid":false,"given":"Muhammad Naveed","family":"Sheas","sequence":"additional","affiliation":[{"name":"Department of Diet &amp; Nutritional Sciences The University of Lahore Islamabad Campus  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Iftikhar","sequence":"additional","affiliation":[{"name":"Department of Diet &amp; Nutritional Sciences The University of Lahore Islamabad Campus  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheraz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Food Science Cholistan University of Veterinary and Animal Sciences  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Adnan","family":"Nasir","sequence":"additional","affiliation":[{"name":"University Institute of Diet &amp; Nutritional Sciences The University of Lahore Gujrat Campus  Gujrat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazala","family":"Kausar","sequence":"additional","affiliation":[{"name":"School of Food and Nutrition Minhaj University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammad ul Islam","family":"Javed","sequence":"additional","affiliation":[{"name":"FMU Faisalabad Medical University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3350-4112","authenticated-orcid":false,"given":"Waseem","family":"Safdar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Medical Sciences  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8882-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0640069"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2010.08.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386\u20106346(98)00026\u20106"},{"key":"e_1_2_9_6_1","first-page":"228","article-title":"Murraya\n                  koenigii attenuates diet\u2010induced hypercholesterolemia in rats","volume":"11","author":"Arafa H. 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