{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:31:26Z","timestamp":1787823086039,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009122","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bananas, one of the most widely consumed fruits worldwide, are a rich source of valuable phytochemicals. In this study, the antioxidant and the anticancer potential of banana flesh was investigated. Of the four kinds of banana flesh extracts, the hexane extract (HE) had the highest total polyphenol content (2.54\u00a0\u00b1\u00a00.60\u00a0mg\u00a0GAE\/g) and total flavonoid content (1.69\u00a0\u00b1\u00a00.34\u00a0mg\u00a0RE\/g), followed by the chloroform fraction, total ethanol extract, and ethanol fraction. HE was found to exert a strong radical scavenging activity on 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH\u2022) and 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonicacid) (ABTS\u2022) free radicals. According to the IC<jats:sub>50<\/jats:sub> values in various cancer cell lines, HE was found to possess the greatest cell growth inhibitory potential in human pancreatic cancer PANC\u20101 cells and human triple\u2010negative breast cancer MDA\u2010MB\u2010231 cells. HE induced apoptosis in PANC\u20101 and MDA\u2010MB\u2010231 cells, as evidenced by the appearance of condensation of chromatin, proteolytic activation of caspase\u20103 and 7, and increase in the level of the cleaved form of poly (ADP\u2010ribose) polymerase protein. Gas chromatography mass spectrometry (GC\u2010MS) analysis of HE identified several anticancer compounds including palmitic acid, linoleic acid, oleic acid, campesterol, stigmasterol, and \u03b3\u2010sitosterol, supporting the anticancer potential of HE. Our investigation provides a rationale for the use of banana flesh to minimize the risk of cancer\u2010like diseases.<\/jats:p>","DOI":"10.1002\/fsn3.2702","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T09:44:09Z","timestamp":1643190249000},"page":"740-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Antioxidant activity of banana flesh and antiproliferative effect on breast and pancreatic cancer cells"],"prefix":"10.1002","volume":"10","author":[{"given":"Dae Kyeong","family":"Kim","sequence":"first","affiliation":[{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meran Keshawa","family":"Ediriweera","sequence":"additional","affiliation":[{"name":"Subtropical\/Tropical Organism Gene Bank Jeju National University  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munkhtugs","family":"Davaatseren","sequence":"additional","affiliation":[{"name":"Subtropical\/Tropical Organism Gene Bank Jeju National University  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Bong","family":"Hyun","sequence":"additional","affiliation":[{"name":"Biodiversity Research Institute Jeju Technopark  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-2005","authenticated-orcid":false,"given":"Somi Kim","family":"Cho","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University  Jeju South Korea"},{"name":"Subtropical\/Tropical Organism Gene Bank Jeju National University  Jeju South Korea"},{"name":"Department of Biotechnology College of Applied Life Sciences Jeju National University  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8391398"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-021-00549-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.10.018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109061"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"28","article-title":"Antioxidant activities and anticancer screening of extracts from banana fruit (Musa sapientum)","volume":"8","author":"Dahham S. 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