{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:37:33Z","timestamp":1790710653540,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Varicocele is considered the main reason for male infertility. Antioxidants are common drugs used to reduce the complications of varicocele in these patients. So, we investigated the effects of lycopene on sperm quality, testicular histology, and the expression of some genes in experimentally induced varicocele. Fifty adult male Wistar rats were divided into three groups: control (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012), sham (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05), and varicocele (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a033) groups. After 2\u00a0months of induced varicocele, five rats were randomly sacrificed and induced varicocele was investigated in each group. Finally, 35 rats were divided into five groups: the control, varicocele, varicocele reserving solvent, and varicocele reserving lycopene (4 and 10\u00a0mg\/kg) for 2\u00a0months. At the end of the experiment, sperm viability, membrane integrity, the expression of Bax, Bcl2, hypoxia (hypoxia\u2010inducible factor 1\u03b1 [HIF1\u2010\u03b1]), heat\u2010shock protein (heat\u2010shock protein A2 [HSPA2]) genes, and the histology of testes were measured. The results showed a significant decrease in the sperm viability, membrane integrity, Johnson's score, and the expression of the Bcl2 gene in the varicocele group compared to the control group. Also, there was a significant increase in Bax, HSPA2, and HIF1\u2010\u03b1 expressions in the varicocele group compared to the control group. Although the administration of lycopene (10\u00a0mg\/kg) in rats with varicocele improved sperm viability and membrane integrity, Johnson's score, and Bax expression compared to the varicocele group. Our findings indicated that the administration of lycopene in the varicocele group improved sperm quality and testicular injury induced by varicocele via decreasing apoptosis.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.2762","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T09:59:14Z","timestamp":1648202354000},"page":"1469-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-7426","authenticated-orcid":false,"given":"Atefeh","family":"Babaei","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Tabriz  Tabriz 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