{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:11:33Z","timestamp":1791396693478,"version":"4.3.3"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the current study, 40 albino male rats were investigated to evaluate the impact of Nano\u2010curcumin (Nano\u2010CUR) administration against Tartrazine (TZ)\u2010induced variations in kidney and liver histology and their related functions. The liver function biomarkers are (glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma\u2010glutamyl transaminase (GGT), alkaline phosphatase (ALP), total bilirubin (T. BiLL)), whereas the kidney biomarkers are (creatinine, uric acid, urea, globulin, total protein (TP)), as well as blood parameters of (serum glucose (sGlu), alpha\u2010fetoprotein (AFP), protein Kinase\u2010C (PKC)) and lipid profiles that include (total lipids (TL), triglyceride (TG), total cholesterol (TC), low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C), high\u2010density L\u2010C (HDL\u2010C), and very\u2010low\u2010density L\u2010C (VLDL\u2010C)). The collected rats were randomly separated into four different groups (G1, G2, G3, and G4) of 10 rats each, where G1 stands for control, G2 for TZ\u2010ingestion, G3 for Nano\u2010CUR\u2010ingestion, and G4 for (TZ\u00a0+\u00a0Nano\u2010CUR mix.) ingestion. TZ\u2010ingestion significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) increases the liver function enzymes\u2019 activity, total bilirubin and kidney biomarkers (creatinine, urea, uric acid, total protein (TP), globulin (Glu)). Also, TZ\u2010ingestion significantly increased sGlu, PKC, AFP, as well as lipid profiles, while there were significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) decreases in HDL\u2010C and albumin (Alb) concentrations compared to control. Histopathological changes in liver, such as dilatation of blood sinusoids and central vein with hemorrhage and necrosis, were observed due to TZ\u2010ingestion. Similarly, TZ\u2010ingestion influenced kidney tissues in terms of tubular dilatation with tubular degeneration, thickened basement membrane, and dilatation of the glomerular capillaries. Markedly, the administration of Nano\u2010CUR significantly decreased liver and kidney function enzymes as well as sGlu, AFP, and PKC, whereas it significantly increased serum Alb and HDL\u2010C levels compared to control and TZ\u2010ingested rats. All values arranged around normal control values. Also, the liver tissue of Nano\u2010CUR\u2010ingested rats showed a normal arrangement of normal blood sinusoids(s), hepatic cords, and hepatocytes as compared to controls. The same results were also found in the section of rat kidney ingested with 2.00\u00a0g of Nano\u2010CUR\/(kg B.W.) showing near\u2010normal architecture as compared to control rats. The liver tissue of rats ingested by a mixture of (7.5\u00a0mg of TZ\u00a0+\u00a02.0\u00a0g of Nano\u2010CUR\/kg B.W.) showed little necrosis. Similarly, a section of rat kidney ingested a mixture of (7.5\u00a0mg of TZ\u00a0+\u00a02.00\u00a0g of Nano\u2010CUR\/kg B.W.) which revealed mild tubular degeneration and dilatation of the glomerular capillaries. These results support the protective and therapeutic effects of Nano\u2010CUR on the histology of liver and kidneys and their related function biomarkers. Also, Nano\u2010CUR corrects the imbalance in serum glucose (sGlu), AFP, PKC, and lipid profiles in TZ\u2010ingested rats compared to control.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.2790","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T07:58:15Z","timestamp":1647849495000},"page":"1344-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of Nano\u2010curcumin effects against Tartrazine\u2010induced abnormalities in liver and kidney histology and other biochemical parameters"],"prefix":"10.1002","volume":"10","author":[{"given":"Gaber E.","family":"El\u2010Desoky","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Science King Saud University  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-5556","authenticated-orcid":false,"given":"Saikh M.","family":"Wabaidur","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science King Saud University  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeid A.","family":"AlOthman","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science King Saud University  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Habila","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science King Saud University  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"615","article-title":"Physiological effects of some synthetic food colouring additives on rats","volume":"136","author":"Aboel\u2010Zahab H.","year":"1997","journal-title":"Bollettino Chimico Farmaceutico"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.03.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.06.033"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb01407.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1373"},{"key":"e_1_2_9_7_1","first-page":"85","article-title":"Assessment of the changes in some diagnostic parameters in male albino rats fed on an Azo Dye","volume":"4","author":"Al\u2010Shinnawy M. 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