{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:43:10Z","timestamp":1774568590691,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["63292"],"award-info":[{"award-number":["63292"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent evidence indicates that propolis can modulate gastrointestinal (GI) function. This trial aims to assess the efficacy of propolis supplementation on the severity of irritable bowel syndrome (IBS) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical trial was conducted on 56 subjects with IBS diagnosed by Rome IV criteria. Eligible subjects were randomly assigned to receive either 900\u00a0mg\/day of propolis or matching placebo tablets for 6\u00a0weeks. The IBS symptom severity scale (IBS\u2010SSS) was used to evaluate IBS severity in five clinically applicable items.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting anxiety scores, a significant reduction was observed in the overall score of IBS symptoms (\u221298.27\u00a0\u00b1\u00a0105.44), the severity of abdominal pain (\u221224.75\u00a0\u00b1\u00a028.66), and the frequency of abdominal pain (\u22122.24\u00a0\u00b1\u00a03.51) with propolis treatment as compared to placebo (<jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a0.05). Patients in the propolis group were 6.22 times more likely to experience improvement in IBS symptoms than those in the placebo group (95% CI: 1.14\u201333.9; <jats:italic>p<\/jats:italic>\u2010value: .035). There was no significant change in anthropometric measurements and dietary intakes in both groups (<jats:italic>p<\/jats:italic>\u2010value\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results showed that propolis supplementation might have a beneficial effect on constipation subtype of IBS (IBS\u2010C) and mixed subtype of IBS (IBS\u2010M) severity by reducing the severity and frequency of abdominal pain in patients with irritable bowel syndrome (IBS).<\/jats:p><\/jats:sec>","DOI":"10.1002\/fsn3.2806","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T16:04:52Z","timestamp":1650470692000},"page":"1899-1907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of propolis supplementation on irritable bowel syndrome with constipation (IBS\u2010C) and mixed (IBS\u2010M) stool pattern: A randomized, double\u2010blind clinical trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-6911","authenticated-orcid":false,"given":"Mahsa","family":"Miryan","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center Department of Clinical Nutrition School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutritional Sciences Department School of Nutritional Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-3743","authenticated-orcid":false,"given":"Davood","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Nutritional Sciences Department School of Nutritional Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Research Center of Oils and Fats Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pejman","family":"Alavinejad","sequence":"additional","affiliation":[{"name":"Hepatology Department School of Medicine Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Abbaspour","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Ostadrahimi","sequence":"additional","affiliation":[{"name":"Nutrition Research Center Department of Clinical Nutrition School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31827febfd"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.03.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.721"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13642"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2016.16301"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.743"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00412"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20108741(91)90135\u2010Z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.1997.142318000.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887\u20106185(92)90026\u20104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14650"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010016\u20101224\u2010y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494412"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102380"},{"issue":"5","key":"e_1_2_9_17_1","first-page":"197","article-title":"Mechanisms involved in the antiinflammatory effect of propolis extract","volume":"19","author":"Khayyal M.","year":"1993","journal-title":"Drugs under Experimental and Clinical Research"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbm.2019.75018"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114\u2010011\u20100770\u20107"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010020\u201004615\u20105"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.167270"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4272940"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201018144"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104\u201079302000000200006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.252.ccm"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4264"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010018\u20100673\u20105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6759"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095\u20104964(17)60315\u20107"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6856"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6937"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(02)00023\u20105"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.08.001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.96"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050272"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000198"},{"key":"e_1_2_9_37_1","first-page":"2011","article-title":"Inhibitory effect of chinese propolis on phosphatidylcholine\u2010specific phospholipase C activity in vascular endothelial cells","volume":"2011","author":"Xuan H.","year":"2010","journal-title":"Evidence\u2010Based Complementary and Alternative Medicine"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109393"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13050498"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.2806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:27:31Z","timestamp":1692674851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.2806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/fsn3.2806"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.2806","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"assertion":[{"value":"2021-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}