{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:05:55Z","timestamp":1793232355419,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1A\u20105A\u20102008833"],"award-info":[{"award-number":["NRF\u20102015R1A\u20105A\u20102008833"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1I1A3044128"],"award-info":[{"award-number":["2021R1I1A3044128"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (<jats:italic>Crassostrea gigas<\/jats:italic>) with economic value. OBC is a by\u2010product of boiling oysters at 95\u00b0C for 3\u00a0min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single\u2010EtOH\u2010binge\u2010drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca<jats:sup>2+<\/jats:sup> concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF\u2010\u03baB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH\u2010induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects.<\/jats:p>","DOI":"10.1002\/fsn3.2847","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T06:59:57Z","timestamp":1648623597000},"page":"2390-2399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oyster broth concentrate and its major component taurine alleviate acute alcohol\u2010induced liver damage"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-4202","authenticated-orcid":false,"given":"Adrian S.","family":"Siregar","sequence":"first","affiliation":[{"name":"Department of Physiology and Institute of Health Sciences College of Medicine Gyeongsang National University  Jinju South Korea"},{"name":"Department of Convergence Medical Science Gyeongsang National University  Jinju South 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Laboratory Science Masan University  Changwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Hyang","family":"Park","sequence":"additional","affiliation":[{"name":"Sunmarin Biotech Jinju Bioindustry Foundation  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Ryeal","family":"Hahm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital and Institute of Health Sciences College of Medicine Gyeongsang National University  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeung\u00a0Joon","family":"Choi","sequence":"additional","affiliation":[{"name":"Ocean\u2010Pep Jinju Bioindustry Foundation  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-7298","authenticated-orcid":false,"given":"Dawon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of 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