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We investigated the anti\u2010inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro. In a lipopolysaccharide (LPS)\u2010induced acute kidney injury rat model, JCo extract improved animal survival, reduced kidney injury scores, suppressed kidney injury molecule\u20101, and preserved E\u2010cadherin expression from LPS damage, as demonstrated by the immunohistochemistry examinations of the rat kidneys. In LPS\u2010stimulated NRK\u201052E cells, JCo extract inhibited nuclear factor\u2010\u03baB (NF\u2010\u03baB) and increased adenosine monophosphate\u2013activated protein kinase (AMPK) expression, prompting the activation of the antioxidant nuclear factor erythroid 2\u2013related factor\u20102\/heme oxygenase\u20101 pathway against oxidative stress. JCo extract ameliorated LPS\u2010induced acute kidney injury by suppressing NF\u2010\u03baB signaling and stimulating the release of tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 through the AMPK pathway.<\/jats:p>","DOI":"10.1002\/fsn3.2941","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T16:34:25Z","timestamp":1656779665000},"page":"3405-3414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Juniperus communis<\/i> extract ameliorates <scp>lipopolysaccharide\u2010induced<\/scp> acute kidney injury through the adenosine monophosphate\u2013activated protein kinase pathway"],"prefix":"10.1002","volume":"10","author":[{"given":"Ta\u2010Chin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Surgery, National Defense Medical Center Tri\u2010Service General Hospital Penghu Branch  Magong City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nursing Buddhist Tzu Chi General Hospital  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Fu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory and Biotechnology Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-224X","authenticated-orcid":false,"given":"Chung\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing Tzu Chi University of Science and Technology  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/634723"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.07.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X19500605"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa142"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201400439"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211143"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800418759599"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20202083"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800409334750"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00662"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2084"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00477.2005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20108490.65505"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101526\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.026"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092054"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02376"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2012.696609"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.261"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493842"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.19479"},{"issue":"7","key":"e_1_2_9_25_1","first-page":"3338","article-title":"Adiponectin inhibits NLRP3 inflammasome by modulating the AMPK\u2010ROS pathway","volume":"11","author":"Wang F.","year":"2018","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011190"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.03.030"}],"container-title":["Food Science &amp; 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