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However, little is known about the effects of TTO on intestinal amino acid transport and immune function in goats. Twenty\u2010four Ganxi goats (initial body weight of 13.5\u2009\u00b1\u20090.70\u2009kg) were randomly allotted two treatments and fed either control (CON) or CON+TTO (0.2\u00a0ml\/kg) diet. The addition of TTO to the diet significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) tumor necrosis factor\u2010\u03b1 content and increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) interleukin\u20102 (IL\u20102) content in goat serum; significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) IL\u201012, and increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) IL\u20102 content in goat ileal mucosa; significantly increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) secreted IgA content in the jejunal and ileal mucosa; significantly upregulated (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) IL\u20102 and downregulated (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) IL\u201012 at the mRNA level in the ileal mucosa; significantly elevated the levels of serine, arginine, and total amino acids in the ileal mucosa (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05); significantly upregulated (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) SLC1A1 and SLC7A1 in the ileum; and significantly enhanced (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) the protein expression of Claudin\u20101 in the ileal mucosa. In summary, adding 0.2\u2009ml\/kg of TTO to the diet enhanced SLC1A1 and SLC7A1 mRNA expression in the ileal mucosa, and SLC1A1 and SLC7A1 could transport serine and arginine from the chyme to the ileal mucosa. Thus, increased serine and arginine content in the mucosa could improve intestinal immunity. TTO supplementation upregulated the expression of IL\u20102 and Claudin\u20101 in goat ileal mucosa, and enhanced immune function in the intestine.<\/jats:p>","DOI":"10.1002\/fsn3.2972","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T13:15:00Z","timestamp":1657718100000},"page":"3749-3758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dietary tea tree (<i>Melaleuca alternifolia<\/i>) oil supplementation enhances the expressions of amino acid transporters in goat ileal mucosa and improves intestinal immunity"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-4683","authenticated-orcid":false,"given":"Xiaokang","family":"Lv","sequence":"first","affiliation":[{"name":"CAS Key Laboratory for Agro\u2010Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolic Process Institute of Subtropical Agriculture, Chinese Academy of Sciences  Changsha China"},{"name":"College of Advanced Agricultural University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenyang Agricultural University Institute of Rural Revitalization Strategy  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanshe","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Agro\u2010Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolic Process Institute of Subtropical Agriculture, Chinese Academy of Sciences  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