{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:06:51Z","timestamp":1780963611886,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004517","name":"Tianjin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873100"],"award-info":[{"award-number":["81873100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our general purpose was to examine the effect of condensed Fuzheng extract (CFE) on the alleviation of immunosuppression. A mouse model of immunosuppression was established by intraperitoneal injection of CTX. A healthy control group received no CTX and no CFE; different intragastric doses of CFE were administered to three groups of mice for 28\u2009days (4500, 2250, or 1125\u2009mg\/kg\/day); a negative control received CTX alone, and a positive control received CTX and levamisole hydrochloride. We evaluated the effects of CFE on the immune system organs, cells, and molecules by comparing the different groups. CFE significantly improved immune system organs (spleen and thymus indices and histology), stimulated immune cell activities (number of white blood cells and lymphocytes, phagocytosis of mononuclear phagocytes, proliferation of splenic lymphocytes, antibody formation, and NK cell activity), and increased the levels of immunoglobulins (IgA, IgG, and IgM) and cytokines (IL\u20102 and IFN\u2010\u03b3). Thus CFE effectively alleviated CTX\u2010mediated immunosuppression and oxidative stress and enhanced the immunological functions of mice.<\/jats:p>","DOI":"10.1002\/fsn3.2982","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:05:55Z","timestamp":1658138755000},"page":"3865-3875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Condensed Fuzheng extract increases immune function in mice with cyclophosphamide\u2010induced immunosuppression"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-6923","authenticated-orcid":false,"given":"Ji\u2010Da","family":"Wang","sequence":"first","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department Tianjin Second People's Hospital  Tianjin China"},{"name":"School of Intergrative Medicine Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tong","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run\u2010Dong","family":"Chai","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-8682","authenticated-orcid":false,"given":"Ze\u2010Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hong","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-0532","authenticated-orcid":false,"given":"Shu\u2010Wu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Intergrative Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010016\u20103152\u20101"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010020\u201005276\u20100"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116532"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.125"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2001184"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10819"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22535"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.10.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201720160487"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010236"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo00008f"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.04.057"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.318"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed\u20102017\u2010011593"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo00597e"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.08.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040932"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120211"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2019.1588291"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u201000850\u20109"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13071301"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00328"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1603735"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.172"},{"issue":"2","key":"e_1_2_8_30_1","first-page":"346","article-title":"Comparative study of cyclophosphamide, 6\u2010mercaptopurine, azathiopurine and methotrexate. Relative effects on the humoral and the cellular immune response in the mouse","volume":"26","author":"Otterness I. G.","year":"1976","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.03.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201057613\u20108_1"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2017.1392564"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100076\u20107"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030684"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.02.093"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3685213"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113249"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2019.08.002"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.5945"}],"updated-by":[{"DOI":"10.1002\/fsn3.71905","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000}}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.2982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T17:10:46Z","timestamp":1692378646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.2982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/fsn3.2982"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.2982","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2022-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}