{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:10:28Z","timestamp":1782385828260,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["KSN2012320"],"award-info":[{"award-number":["KSN2012320"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The larvae of <jats:italic>Protaetia brevitarsis seulensis<\/jats:italic> have been used as a food ingredient and are known for their nutritional value and anti\u2010inflammatory properties. However, whether <jats:italic>P.\u00a0brevitarsis seulensis<\/jats:italic> larvae demonstrate protective effects against radiation\u2010induced testicular injury has not been investigated. In this study, the protective effects of an aqueous extract of <jats:italic>P.\u00a0brevitarsis seulensis<\/jats:italic> larvae (PBE) against radiation\u2010induced testicular injury were tested. Male C57BL\/6 mice were administered PBE (5 or 10\u00a0mg\/kg) orally for 14\u2009days before exposure to focal pelvic irradiation. Histopathological examinations were conducted at 8\u00a0h and 30 d after radiation exposure. PBE pretreatment reduced the radiation\u2010induced apoptosis of germ cells at 8\u00a0h after irradiation and significantly increased testis and epididymis weights relative to those of the irradiated control mice at 30\u2009days. PBE protected against histopathological damage and decreased the radiation\u2010induced effects on the epithelium height and seminiferous tubule diameter. Furthermore, the extract ameliorated the radiation\u2010induced morphological abnormalities of sperm cells and improved their motility. It also prevented a decrease in the epididymal sperm count caused by irradiation. Moreover, the extract alleviated the generation of reactive oxygen species, and its antioxidative activity increased in a dose\u2010dependent manner. Among the six major compounds isolated from PBE, benzoic acid and uridine showed the highest antioxidant activities. These results suggest that PBE protects against radiation\u2010induced testicular injury via its antioxidative properties. Thus, it has potential clinical applicability as a neoadjuvant therapy for the prevention of testicular damage caused by cancer radiotherapy.<\/jats:p>","DOI":"10.1002\/fsn3.2992","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T15:05:52Z","timestamp":1663686352000},"page":"3969-3978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Protective effects of an aqueous extract of <i>Protaetia brevitarsis seulensis<\/i> larvae against radiation\u2010induced testicular injury in mice"],"prefix":"10.1002","volume":"10","author":[{"given":"Hyeon\u2010Hwa","family":"Nam","sequence":"first","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohi","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-3495","authenticated-orcid":false,"given":"Yun\u2010Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Cheol","family":"Moon","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae June","family":"Lee","sequence":"additional","affiliation":[{"name":"Divison of Radiation Biomedical Research Korea Institute of Radiological and Medicinal Sciences  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Semyung University  Jecheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohye","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueun","family":"Lee","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-4860","authenticated-orcid":false,"given":"Joong\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"},{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/088800100276631"},{"key":"e_1_2_10_5_1","first-page":"667","article-title":"Camargo ACd, Vieira TMFdS phenolic compounds and antioxidant activity of hydroalcoholic extracts of wild and cultivated murtilla (Ugni molinae Turcz) Food Sci","volume":"34","author":"Augusto T.","year":"2014","journal-title":"Technology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258266"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109422(01)00137\u20106"},{"issue":"8","key":"e_1_2_10_8_1","first-page":"12487","article-title":"The radioprotective effects of Moringa oleifera against mobile phone electromagnetic radiation\u2010induced infertility in rats","volume":"8","author":"Bin\u2010Meferij M. 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