{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:05:48Z","timestamp":1747148748882,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["4069\u2010145194"],"award-info":[{"award-number":["4069\u2010145194"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During pregnancy, vitamin D deficiency is associated with negative health consequences for mother and child. Furthermore, dark skin color is associated with lower vitamin D levels. We investigated 25\u2010hydroxy\u2010vitamin D (25(OH)D) and parathyroid hormone (PTH) levels in mothers and in cord blood of their newborns depending on maternal skin color. We recruited 202 mother and child pairs at the University Hospital Zurich and measured 25(OH)D and PTH concentrations in maternal and postpartum umbilical cord blood. Skin type was self\u2010reported based on the Fitzpatrick Scale (type I to V). Uni\u2010 and multivariate methods were used to compare the maternal and neonatal 25(OH)D and PTH levels by skin type (light: I\u2013III vs. dark: IV\u2013V). As many as 54.5% of all mothers and 41.1% of the neonates were 25(OH)D deficient. This was higher in the neonates of dark\u2010skinned (55.9%) than in the neonates of light\u2010skinned mothers (38.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). The correlation of 25(OH)D in the maternal with umbilical cord blood was high (light: r\u00a0=\u00a00.85, dark: r\u00a0=\u00a00.87), with higher concentrations of 25(OH) vitamin D in the umbilical cord than in maternal blood. Regression analysis revealed that country of origin and maternal 25(OH)D concentration were the only statistically significant determinants for umbilical cord blood 25(OH)D. We observed no correlation of maternal with umbilical cord PTH concentrations; median PTH concentrations in the umbilical cord (5.6\u00a0pg\/ml) were significantly lower than in maternal blood (25.7\u00a0pg\/ml). The recommendation of vitamin D supplementation in newborns in their first 3\u2009years of life should be particularly emphasized to dark\u2010skinned mothers.<\/jats:p>","DOI":"10.1002\/fsn3.3013","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T11:53:40Z","timestamp":1659700420000},"page":"4201-4208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D and parathyroid hormone in the umbilical cord blood \u2013 Correlation with light and dark maternal skin color"],"prefix":"10.1002","volume":"10","author":[{"given":"Klara","family":"Wille","sequence":"first","affiliation":[{"name":"Department of Obstetrics University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Richard","sequence":"additional","affiliation":[{"name":"Epidemiology Biostatistics and Prevention Institute, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Nieters","sequence":"additional","affiliation":[{"name":"FREEZE\u2010Biobank, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-1200","authenticated-orcid":false,"given":"Sabine","family":"Rohrmann","sequence":"additional","affiliation":[{"name":"Epidemiology Biostatistics and Prevention Institute, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-4829","authenticated-orcid":false,"given":"Katharina","family":"Quack L\u00f6tscher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2651"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152198"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00802.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.8.1376"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0718"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.2.447"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03316.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104807"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120873"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2017.09.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00306.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0093-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.02.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060015008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770217"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60211-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082419"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001840"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-4-652"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.6.7575"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2011.08.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2015"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517003634"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00126.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-006-0007-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456328702400103"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.13028"},{"volume-title":"Weight gain during pregnancy: Reexamining the guidelines","year":"2009","author":"Rasmussen K. 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