{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:37:58Z","timestamp":1773049078478,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) is characterized by cellular damage and inflammation in lesioned brain tissue. Ferulic acid has been shown to have a melioration effect on neurological functions. However, the active pharmacological effects and the underlying mechanisms of ferulic acid against TBI remain unclear. On the basis of network pharmacology and molecular docking methodology, this study aimed to investigate the beneficial effects of ferulic acid in treating TBI, and characterized the detailed biotargets and mechanisms of these actions. The identified core targets were validated via in silico simulation. We identified 91 overlapping targets associated with ferulic acid and TBI. In\u2010silico simulation analysis validated the putative core targets of tumor protein p53, mitogen\u2010activated protein kinase (MAPK) 1, and estrogen receptor 1. The Gene Ontology\u2010enriched annotations and findings were largely associated with cell proliferation, apoptosis, and inflammation in nerve cells. Additional Kyoto Encyclopedia of Genes and Genomes enrichment analysis unmasked the pharmacological pathways of ferulic acid in treating TBI, including the MAPK signaling pathway and hypoxia\u2010inducible factor\u20101 signaling pathway. Bioinformatic analyses and findings provide a new preclinical strategy for revealing the core targets and network pathways of ferulic acid in treating TBI. Moreover, some bioinformatic findings were computationally validated in silico for exhibiting the neuroprotective action of ferulic acid against TBI.<\/jats:p>","DOI":"10.1002\/fsn3.3036","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T07:34:05Z","timestamp":1661499245000},"page":"4403-4410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preclinical findings reveal the pharmacological targets of ferulic acid in the treatment of traumatic brain injury"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-6655","authenticated-orcid":false,"given":"Qinghua","family":"Dong","sequence":"first","affiliation":[{"name":"Intensive Care Unit Guilin Municipal Hospital of Traditional Chinese Medicine  Guilin Guangxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Guilin Municipal Hospital of Traditional Chinese Medicine  Guilin Guangxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafeng","family":"Liao","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Guilin Municipal Hospital of Traditional Chinese Medicine  Guilin Guangxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Guilin Municipal Hospital of Traditional Chinese Medicine  Guilin Guangxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Guilin Municipal Hospital of Traditional Chinese Medicine  Guilin Guangxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.06.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1132-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.04.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101624"},{"key":"e_1_2_8_6_1","first-page":"372","article-title":"The effect of ferulic acid on experimental traumatic brain damage in rats","volume":"120","author":"Erbil G.","year":"2019","journal-title":"Bratislavsk\u00e9 Lek\u00e1rske Listy"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30182-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.05.036"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.028"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.10.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.21307\/ane-2021-027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-175-2_12"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.045"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa300"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa141"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21146"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106379"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10102089"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495078"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800420912335"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126418"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100185"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88313-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99397-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16117"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14696.1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111305"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102653"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091420910957"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.870370"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4200"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001538"}],"container-title":["Food Science &amp; 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