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In the current study, we used chromatography of gel filtration to identify a novel peptide (<jats:italic>Lignosus rhinocerotis<\/jats:italic> peptide [LRP]) from the sclerotium of <jats:italic>Lignosus rhinocerotis<\/jats:italic> (Cooke) Ryvarden. Its neuroprotective effect was evaluated using an in vitro PD model constructed by 6\u2010hydroxydopamine (6\u2010OHDA)\u2010stimulated to apoptosis in PC12 cells. The molecular weight of LRP is determined as 1532\u2009Da and the secondary structure is irregular. The simple amino acid sequence of LRP is Thr\u2010Leu\u2010Ala\u2010Pro\u2010Thr\u2010Phe\u2010Leu\u2010Ser\u2010Ser\u2010Leu\u2010Gly\u2010Pro\u2010Cys\u2010Leu\u2010Leu. Notably, LRP has the ability to significantly boost the viability of PC12 cells after exposure to 6\u2010OHDA, as well as enhance the cellular activity of antioxidative enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH\u2010Px). LRP also lowers the level of malondialdehyde (MDA), decreases the activation performance of Caspase\u20103, and reduces 6\u2010OHDA\u2010induced apoptosis via inhibition of nuclear factor\u2010kappa B (NF\u2010\u03baB) activation. These data indicate that LRP may have the potential to act as a neuroprotective agent.<\/jats:p>","DOI":"10.1002\/fsn3.3050","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T13:06:14Z","timestamp":1662987974000},"page":"2152-2165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuroprotective effects of a novel peptide from <i>Lignosus rhinocerotis<\/i> against 6\u2010hydroxydopamine\u2010induced apoptosis in <scp>PC12<\/scp> cells by inhibiting <scp>NF\u2010\u03baB<\/scp> activation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9942-5951","authenticated-orcid":false,"given":"Chuan","family":"Xiong","sequence":"first","affiliation":[{"name":"Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural Sciences  Chengdu 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