{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:17:13Z","timestamp":1791497833271,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900918"],"award-info":[{"award-number":["31900918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to observe the effect of <jats:italic>Inonotus obliquus<\/jats:italic> polysaccharide (IOP) on blood lipids and its regulation on the intestinal flora in hyperlipidemia rats, and explore the modern biological connotation of IOP in reducing blood lipids. In this study, we obtained the crude IOP by the water extraction and alcohol precipitation method, and then classified it by DEAE ion\u2010exchange chromatography to obtain the acidic <jats:italic>I. obliquus<\/jats:italic> polysaccharide (IOP\u2010A). After the administration of the IOP\u2010A, the serum TC, TG, and LDL\u2010C levels were significantly lower, while the serum HDL\u2010C levels were significantly higher. The expression of CYP7A1 protein was considerably increased, whereas the expression of SREBP\u20101C protein was considerably decreased in the rat hepatic tissue. In addition, the IOP\u2010A could significantly alleviate the hepatocyte fatty degeneration in the liver lobule of rats. We believe that the IOP\u2010A can affect the composition of intestinal flora by reducing the relative abundance of Firmicutes and increasing the relative abundance of Bacteroidetes. These findings indicated that the IOP\u2010A can regulate the dyslipidemia of hyperlipidemia rats, and its mechanism may be through regulating the CYP7A1 and SREBP\u20101C expression in the metabolism of lipids, and correcting the imbalance of intestinal flora structure caused by a high\u2010fat diet.<\/jats:p>","DOI":"10.1002\/fsn3.3052","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T18:05:45Z","timestamp":1664129145000},"page":"191-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Study on the hypolipidemic effect of <i>Inonotus obliquus<\/i> polysaccharide in hyperlipidemia rats based on the regulation of intestinal flora"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-5951","authenticated-orcid":false,"given":"Fengyuan","family":"Lin","sequence":"first","affiliation":[{"name":"College of Pharmacy Beihua University  Jilin 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