{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:21Z","timestamp":1786977741830,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the past few decades, more alcohol\u2010problem concerns focused on reducing the risk of hangover caused by the alcoholic beverages over\u2010consumption. Chinese distilled spirits (Baijiu) is one of the most favorite alcoholic beverages. The intention of this study is to explore the associations of main flavor components in Baijiu and hangover symptoms using mice acute alcohol withdrawal model. The behaviors of each mouse were assessed by open\u2010field tests using separate groups of mice with the treatment of sauce\u2010aroma Baijiu, light\u2010aroma Baijiu, strong\u2010aroma Baijiu, pure alcohol, and distilled water, respectively. The behavioral data including total move distance and immobile time were used as indicators for the evaluation of the liquor intoxicating effects. Alcohol and acetaldehyde concentrations in mice plasma and the neurotransmitter contents of GABA and Glu in mice cerebellum were detected afterward. The results showed that the mice with the treatment of Baijiu samples displayed unusual exciting behaviors including increased alcohol metabolization with alleviating drunken and hangover symptoms, compared with that of pure alcohol control groups after 2\u20134\u00a0h. Moreover, the sauce\u2010aroma Baijiu treatment group showed lessening intoxicated symptoms than those of light\u2010aroma Baijiu and strong\u2010aroma Baijiu. In addition, there were significant differences between Baijiu and pure alcohol treatment groups at the inhibitory neurotransmitter GABAergic levels and its receptor GABA\u2010AR1 activating levels in the mice neuron cells. Furthermore, the Principal Component Analysis (PCA) analysis inferred that the flavor compounds acetic acid, ethyl acetate, ethyl lactate, and 1\u2010propanol in the sauce\u2010aroma Baijiu were played the major roles in the drunk behaviors that caused by the hangover. While, the acetic acid in the sauce\u2010aroma Baijiu was speculated as a major flavor component to accelerate the alcohol metabolism and retard hangover symptoms.<\/jats:p>","DOI":"10.1002\/fsn3.3064","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T08:58:02Z","timestamp":1663577882000},"page":"334-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating and forecasting the associated main flavor components in Baijiu (Chinese distilled spirits) with alcohol metabolism and hangover symptoms through mice acute withdrawal model"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-1577","authenticated-orcid":false,"given":"Jie","family":"Huangfu","sequence":"first","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Guizhou Guotai Liquor Co., Ltd.  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwen","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou Guotai Liquor Co., Ltd.  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Wang","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Luan","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-7294","authenticated-orcid":false,"given":"Xinlin","family":"Han","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Beijing City University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchao","family":"He","sequence":"additional","affiliation":[{"name":"China National Research Institute of Food &amp; 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