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Notably, many attempts to the reduction of the complications of poststroke injuries like depression have failed so far. In this study, we aimed to evaluate the anti\u2010inflammatory effect of arthrocen, avocado\/soybean unsaponifiables (ASU), in the poststroke injuries like depression improvement in a mice model. We examined the antidepressant\u2010like effect of arthrocen using the forced swimming test and tail suspension test in mice subjected to stroke. Furthermore, immunohistochemistry of proinflammatory cytokines, IL\u201010 and TNF\u2010\u03b1, and neural cell count were performed in the ischemic brain hippocampus of mice. Oral arthrocen reduced significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) the immobility time in the forced swimming test and tail suspension test in the stroke animals. Also, immunohistochemistry analysis of the hippocampus indicated significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.01) the reduction of IL\u201010 and TNF\u2010\u03b1 cytokines production. Nissl staining showed a significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001) increase in the number of viable neurons in stroke mice receiving arthrocen. In conclusion, our data revealed the antidepressant activity of arthrocen in the stroke mice which may be the result of its anti\u2010inflammatory and neuroprotective role.<\/jats:p>","DOI":"10.1002\/fsn3.3083","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T18:25:42Z","timestamp":1664994342000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Beneficial effects of arthrocen on neuroinflammation and behavior like depression in stroke in a murine model"],"prefix":"10.1002","volume":"11","author":[{"given":"Ramin","family":"Goudarzi","sequence":"first","affiliation":[{"name":"Division of Research and Development, Pharmin USA LLC  San Jose California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Golnaz","family":"Zamanian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Tehran University of 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