{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:46:48Z","timestamp":1789512408953,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prolongation of life span has attracted more and more attention in the current world. Gut microbiota is considered one of the most critical elements and is essential in regulating life span and quality. The effects of donkey whey protein (DWP) and donkey whey hydrolysate (DWPP) on physiological functions and gut microbiota of D\u2010galactose\u2010induced aging mice were investigated to find new strategies for resisting aging. Our results showed that DWP and DWPP could increase the body weight gain velocity, superoxide dismutase (SOD) activity, and thymus index, whereas decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and improve the aging of the body in the liver congestion, oozy draw focal sclerosis of chronic inflammation. The effects of medium and high concentrations of DWP and low and medium concentrations of DWPP were the same as the vitamin C (Vc)\u2010positive control group. It was found that both DWP and DWPP could change \u03b1\u2010diversity; the relative abundance of <jats:italic>Lactobacillus<\/jats:italic> increased, whereas the relative abundance of <jats:italic>Helicobacter<\/jats:italic> and <jats:italic>Stenotrophomonas<\/jats:italic> decreased after being treated with DWP and DWPP. The correlation between intestinal microflora and physiological indexes showed that chao1, ACE, and observed species indexes in the \u03b1 index were positively correlated with weight gain velocity, SOD activity, and thymus index. The relative abundance of <jats:italic>Lactobacillus<\/jats:italic> was positively correlated with SOD and thymus index but negatively correlated with MDA. The relative abundance of <jats:italic>Stenotrophomonas<\/jats:italic> was opposite to that of <jats:italic>Lactobacillus<\/jats:italic>. The <jats:italic>Anaerobiospirillum<\/jats:italic>, <jats:italic>Fusobacterium<\/jats:italic>, and <jats:italic>Dubosiella<\/jats:italic> had a significant positive correlation with the weight gain velocity. The study provided a deeper more profound understanding of the potential use of DWP and DWPP in senescence delays.<\/jats:p>","DOI":"10.1002\/fsn3.3111","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T08:55:37Z","timestamp":1666342537000},"page":"752-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Donkey whey protein and peptides regulate gut microbiota community and physiological functions of D\u2010galactose\u2010induced aging mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Xueyan","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Life Science and Engineering Northwest Minzu University  Lanzhou China"},{"name":"China\u2010Malaysia National Joint Laboratory, Biomedical Research Center Northwest Minzu University  Lanzhou China"},{"name":"Gannan Research Institute of Yak Milk  Hezuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Life Science and Engineering Northwest Minzu University  Lanzhou China"},{"name":"China\u2010Malaysia National Joint Laboratory, Biomedical Research Center Northwest Minzu University  Lanzhou China"},{"name":"Gannan Research Institute of Yak Milk  Hezuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Gannan Research Institute of Yak Milk  Hezuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Gannan Research Institute of Yak Milk  Hezuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongren","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Life Science and Engineering Northwest Minzu University  Lanzhou China"},{"name":"China\u2010Malaysia National Joint Laboratory, Biomedical Research Center Northwest Minzu University  Lanzhou China"},{"name":"Gannan Research Institute of Yak Milk  Hezuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-6331","authenticated-orcid":false,"given":"Fumei","family":"Zhang","sequence":"additional","affiliation":[{"name":"China\u2010Malaysia National Joint Laboratory, Biomedical Research Center Northwest Minzu University  Lanzhou China"},{"name":"Gannan Research Institute of Yak Milk  Hezuo China"},{"name":"The Department of Medicine Northwest Minzu University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Official methods of analysis","author":"AOAC","year":"1995"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa048"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2015.1036187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aoas.2013.01.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010019\u201009837\u2010y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14523"},{"key":"e_1_2_10_8_1","volume-title":"A complete guide to quality in small\u2010scale wine making","author":"Considine J. A.","year":"2013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.07.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-008-0079-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd3816"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010017\u20100610\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009252\u20104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2017.1356215"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.048"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms9040464"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.032017.16"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.036"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010016\u20100262\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602\u2010018\u20109427\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.59.198"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490615"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16060181"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/NHA\u2010150002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019\u201017448"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz263"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010016\u20100307\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248329"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u20109\u2010123"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029918000687"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010016\u20100708\u20105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2014.01.013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac8469"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010015\u20100386\u20108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100457\u20108"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16\u201000029"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119829518"},{"issue":"1","key":"e_1_2_10_39_1","first-page":"65","article-title":"Heart rate and endocrine responses to stress in adolescent male rhesus monkeys on Cayo Santiago","volume":"8","author":"Rasmussen K. L.","year":"1989","journal-title":"Puerto Rico Health Sciences Journal"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsec.2005.01.003"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700484"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110795"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo00197e"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010017\u20102674\u2010y"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010019\u20100700\u20104"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.08.005"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002601\u20107"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.04.021"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2018.04.051"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12403\u2010020\u201000381\u20106"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.019"},{"issue":"6","key":"e_1_2_10_52_1","first-page":"797","article-title":"The substrate\u2010specific impairment of oxidative phosphorylation in liver mitochondria from high\u2010protein\u2010fed chickens","volume":"74","author":"Toyomizu M.","year":"1995","journal-title":"British Journal of Nutrition"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000696"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90010-8"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6113\u20106122.2004"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010019\u20101616\u20102"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.06.006"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr03060c"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.3111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:41:09Z","timestamp":1692438069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.3111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/fsn3.3111"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.3111","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2022-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}