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Partially hydrolyzed guar gum (PHGG), which is a water\u2010soluble dietary fiber, is known to have a constipation\u2010improving effect. However, many aspects of the mechanism remain unclear. In this study, we investigated the role of aquaporin\u20103 (AQP3), which regulates the water content of feces in ameliorative effect of PHGG on constipation. Rats were allowed to freely consume a normal diet or a diet containing 5% PHGG for 14\u2009days, and defecation parameters were measured. We also analyzed the expression levels of genes involved in water transport in the colon. The defecation frequency and volume of rats treated with PHGG were not different from those from the control group, but the fecal water content was significantly increased, and soft stools were observed. The expressions of claudin\u20101, tight junction protein\u20101, and cadherin\u20101, which are involved in tight junctions or\u00a0adherens junctions, were almost the same in the PHGG\u2010treated group and the control group. The expression level of AQP3 in the colon was significantly decreased in the PHGG\u2010treated group. In this study, PHGG decreased the colonic AQP3 expression, thereby suppressing water transport from the luminal side to the vascular side and improving constipation.<\/jats:p>","DOI":"10.1002\/fsn3.3150","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T04:39:29Z","timestamp":1668746369000},"page":"1127-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of partially hydrolyzed guar gum on the expression of aquaporin\u20103 in the colon"],"prefix":"10.1002","volume":"11","author":[{"given":"Risako","family":"Kon","sequence":"first","affiliation":[{"name":"Department of Biomolecular Pharmacology Hoshi University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-2946","authenticated-orcid":false,"given":"Nobutomo","family":"Ikarashi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Pharmacology Hoshi University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Pharmacology Hoshi University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenta","family":"Yasukawa","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nutrition Kanazawa Gakuin University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Taiyo Kagaku Co., Ltd.  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