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The aim of the study was to investigate the health properties of secoisolariciresinol diglucoside (SDG) and anethole from flaxseed and fennel seeds in rats fed with high\u2010fat diet. Histopathological changes in the heart and liver were also examined. Sixty rats were divided into two main groups. Group I (10 rats) was used as a negative control group and fed on the basal diet only. Group II (50 rats) was fed a hypercholesterolemic diet but not given any drugs during the trial for 2\u2009weeks. This group was further divided into five subgroups (10 rats each). One of them was fed on the basal diet and used as a positive control group. However, the other four subgroups were fed on basal diets and anethole (20\u2009mg\/kg\/day, orally), SDG (20\u2009mg\/kg\/day, orally), a mixture of anethole\u2009+\u2009SDG (10\u2009+\u200910\u2009mg\/kg\/day, orally), and atorvastatin (10\u2009mg\/kg\/day, orally) for 6\u2009weeks. Compared to control, treatment with a combination of anethole\u2009+\u2009SDG showed a significant (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.05) improvement in serum levels of triglyceride (TG) (137.88\u2009\u00b1\u20091.61\u2009mg\/dL), total cholesterol\u2010(TC) (180.12\u2009\u00b1\u20098.99\u2009mg\/dL), LDL\u2010C (46.40\u2009\u00b1\u20096.67\u2009mg\/dL), VLDL\u2010C (11.81\u2009\u00b1\u20091.07\u2009mg\/dL), aspartate aminotransferase (AST) (75.97\u2009\u00b1\u20096.92\u2009U\/L), alanine aminotransferase (ALT) (34.83\u2009\u00b1\u20092.17\u2009U\/L), alkaline phosphatase (ALP) (130.65\u2009\u00b1\u20091.05\u2009U\/L), and malondialdehyde (MDA) (30.12\u2009\u00b1\u20091.89\u2009mmol\/g), and improved activities of catalase (70.99\u2009\u00b1\u20093.29\u2009U\/g) and superoxide dismutase (SOD) (35.13\u2009\u00b1\u20092.53\u2009U\/dL) enzymes while SDG and anethole group had relatively less impact. Atorvastatin also improved serum levels of triglyceride, total cholesterol, LDL\u2010C, and VLDL\u2010C significantly and rose serum high\u2010density lipoprotein cholesterol (HDL\u2010C) levels considerably meanwhile it had a minor but negative impact on AST, ALT, and ALP, and negligible impact on activities of MDA, CAT, and SOD enzymes compared to the positive control group. The study revealed that combining anethole and SDG may improve dyslipidemia, improve lipid profile, decrease risks of chronic heart diseases, increase HDL\u2010C, and enhance antioxidant enzymes' activities.<\/jats:p>","DOI":"10.1002\/fsn3.3250","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:34:48Z","timestamp":1676745288000},"page":"2620-2630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions"],"prefix":"10.1002","volume":"11","author":[{"given":"Sana","family":"Noreen","sequence":"first","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib\u2010ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabussam","family":"Tufail","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Badar\u00a0Ul\u00a0Ain","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-8895","authenticated-orcid":false,"given":"Chinaza Godswill","family":"Awuchi","sequence":"additional","affiliation":[{"name":"School of Natural and Applied Sciences Kampala International University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"44","article-title":"The effect of hydroxytyrosol (HXT) and local olive oil (LOO) on lipid profile and histopathological changes in the heart as outcome of induced hyperlipidemia in male rats","volume":"5","author":"Ahmed Q.","year":"2022","journal-title":"International Journal of Medical Sciences"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119617143.ch7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5958\/0973-9130.2019.00135.X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-0961-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/26895293.2020.1792355"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12933"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2022.126965"},{"issue":"4","key":"e_1_2_11_9_1","first-page":"794","article-title":"Protective role of flaxseed oil on hypercholesterolemic rats","volume":"3","author":"Aly\u2010Aldin M. 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