{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:06:30Z","timestamp":1747148790354,"version":"3.40.5"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine\u2010disrupting chemical capable of causing male infertility. This study aimed to explore <jats:italic>Cucumeropsis mannii<\/jats:italic> seed oil effects against mitochondrial damage in rats using bisphenol A. Forty\u2010eight rats were randomly assigned to six groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) of eight rats each and fed the same food and water for 6\u2009weeks. The group A rats were given 1\u2009mL olive oil, while the ones in group B were given bisphenol A at 100\u00a0mL\/kg body weight via oral route. Group C received <jats:italic>C.\u00a0mannii<\/jats:italic> seed oil 7.5\u2009mL\/kg body weight <jats:italic>C.\u00a0mannii<\/jats:italic> seed oil, while group D, group E, and group F were pre\u2010administered bisphenol A at 100\u00a0mL\/kg body weight, followed by treatment with <jats:italic>C.\u00a0mannii<\/jats:italic> seed oil at 7.5, 5, and 2.5\u2009mL\/kg body weight, respectively. Antioxidant enzymes, glutathione, reactive oxygen species, testicular volume, malondialdehyde, body weight, and testicular studies were done using standard methods. The results of the bisphenol A\u2010administered group showed a significant decrease in the antioxidant enzymes, glutathione, body weight, and testicular volume with elevation in the levels of reactive oxygen species, malondialdehyde, and testicular indices. BPA\u2009+\u2009CMSO\u2010treated group showed a significant increase in GPx activity compared with BPA\u2010exposed rats. CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, <jats:italic>C.\u00a0mannii<\/jats:italic> seed oil and bisphenol A co\u2010administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. Our findings suggest that <jats:italic>C.\u00a0mannii<\/jats:italic> seed oil has considerable antioxidant potential which can be explored in therapeutic development against systemic toxicity induced by exposure to bisphenol A. <jats:italic>Cucumeropsis mannii<\/jats:italic> seed oil protects against bisphenol A\u2010induced testicular mitochondria damages.<\/jats:p>","DOI":"10.1002\/fsn3.3260","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T07:55:58Z","timestamp":1675842958000},"page":"2631-2641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Cucumeropsis mannii<\/i> seed oil protects against <scp>Bisphenol A<\/scp>\u2010induced testicular mitochondrial damages"],"prefix":"10.1002","volume":"11","author":[{"given":"Patrick Maduabuchi","family":"Aja","sequence":"first","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"},{"name":"Department of Biochemistry Kampala International University  Bushenyi Uganda"},{"name":"Department of Biochemistry Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary Akobi","family":"Ogwoni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Chinedu","family":"Agu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ejike Ugbala","family":"Ekpono","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua Nonso","family":"Awoke","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver Ugochukwu","family":"Ukachi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obasi Uche","family":"Orji","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-066X","authenticated-orcid":false,"given":"Boniface Anthony","family":"Ale","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinonso Peter","family":"Nweke","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikechukwu Okorie","family":"Igwenyi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Ugo","family":"Alum","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlington C.","family":"Chukwu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian E.","family":"Offor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ebonyi State University  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atamgba Agbor","family":"Asuk","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Cross River University of Technology (CRUTECH)  Calabar Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ejike Daniel","family":"Eze","sequence":"additional","affiliation":[{"name":"Department of Physiology Kabale University  Kabale Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ojochenemi E.","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University Wukari  Wukari Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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