{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:45:27Z","timestamp":1785465927543,"version":"3.56.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation may develop due to internal dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein or external factors in patients with cystic fibrosis (CF). This prospective randomized clinical trial aimed to ascertain the effects of nano\u2010curcumin as an anti\u2010inflammatory agent and a CFTR modulator on clinical and inflammatory markers in children with CF. Children with CF were randomly assigned to receive daily curcumin or a placebo for 3\u2009months. The primary outcome measure was to evaluate inflammatory indices, nasopharyngeal swab analysis, and clinical assessments via spirometry, anthropometric measurements, and quality of life (QOL) analysis. Sixty children were included. Intra\u2010group changes comparison showed that curcumin decreased the level of high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) (median: \u22120.31\u2009mg\/L, IQR: \u22121.53 to 0.81; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) and fecal calprotectin level (\u221229\u2009\u03bcg\/g, \u221257.5 to 11.5; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03), also increased the level of interleukin (IL)\u201010 (6.1\u00a0pg\/mL, 4.5\u20139; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Moreover, curcumin improved the overall QOL and the subscales of the questionnaire. Inter\u2010group changes comparison depicted the number of <jats:italic>Pseudomonas<\/jats:italic> colonies reduced by about 52% in the curcumin group and gained weight by about 16% (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Nano\u2010curcumin seems to be considered as an effective nutritional supplement on hs\u2010CRP, IL\u201010, fecal calprotectin levels, and improving QOL in patients with CF.<\/jats:p>","DOI":"10.1002\/fsn3.3323","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:42:19Z","timestamp":1680014539000},"page":"3348-3357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adjunctive nano\u2010curcumin therapy improves inflammatory and clinical indices in children with cystic fibrosis: A randomized clinical trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Saeedeh","family":"Talebi","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahammad","family":"Safarian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Javad","family":"Sayedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood Reza","family":"Jaafari","sequence":"additional","affiliation":[{"name":"Nanotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Akbar Clinical Research and Development Unit Mashhad University of Medical 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