{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:30:16Z","timestamp":1787563816341,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The formation and release of eggs during ovulation are impacted by high amounts of androgens. Seed cycling is powerful in the treatment of polycystic ovary syndrome (PCOS). For efficacy studies, 90 women with PCOS, between 15 and 40\u2009years were selected from the department of gynecology, Tertiary care unit. Women with PCOS were divided into three groups (T\n                    <jats:sub>0<\/jats:sub>\n                    , T\n                    <jats:sub>1<\/jats:sub>\n                    , T\n                    <jats:sub>2<\/jats:sub>\n                    ) (20 women\/group). Among these three groups, the first was the control group (T\n                    <jats:sub>0<\/jats:sub>\n                    ). The second group was the experimental group (T\n                    <jats:sub>1<\/jats:sub>\n                    ). In T\n                    <jats:sub>1<\/jats:sub>\n                    , 20 women with PCOS were treated with a portion control diet and METFORMIN 500\u2009mg tab\/day for 90\u2009days. The third group was also an experimental group (T\n                    <jats:sub>2<\/jats:sub>\n                    ). In this group, 20 women with PCOS were also treated with another treatment plan for 90\u2009days, in which portion control diet and seed cycling were included. During the 12\u2010week efficacy trial, the highest follicle stimulating hormone (FSH) levels were found in the control group T\n                    <jats:sub>0<\/jats:sub>\n                    (8.18\u2009\u00b1\u20090.13\u2009mIU\/mL). In T\n                    <jats:sub>2<\/jats:sub>\n                    , FSH falls from 6.545\u2009\u00b1\u20090.16\u2009mIU\/mL to 3.51\u2009\u00b1\u20090.13\u2009mIU\/mL throughout a 12\u2010week period. Overall, a portion\u2010controlled diet and seed cycling reduced FSH levels by 1.2% to 2.5%. LH value was 10.118\u2009\u00b1\u20090.1874\u2009IU\/L in the control group (T\n                    <jats:sub>0<\/jats:sub>\n                    ), which climbed 12.82\u2009\u00b1\u20090.15\u2009IU\/L, but decreased from 10.62\u2009\u00b1\u20090.26\u2009IU\/L to 9.79\u2009\u00b1\u20090.17\u2009U\/L and 11.015\u2009\u00b1\u20090.24\u2009IU\/L 6.217\u2009\u00b1\u20090.167\u2009IU\/L in the other groups (T\n                    <jats:sub>1<\/jats:sub>\n                    , T\n                    <jats:sub>2<\/jats:sub>\n                    ). It was determined that the LH levels were reduced by 1.5%\u20132% in T\n                    <jats:sub>2<\/jats:sub>\n                    . Conclusively, the seed cycling approach is effective and has significant results in women with PCOS. Seed cycling improves hormonal disturbance in women which promotes a healthy life.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.3328","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T15:33:42Z","timestamp":1679758422000},"page":"3385-3393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females"],"prefix":"10.1002","volume":"11","author":[{"given":"Naveed","family":"Rasheed","sequence":"first","affiliation":[{"name":"Department of Home Economics Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Nosheen","sequence":"additional","affiliation":[{"name":"Department of Home Economics Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-8066","authenticated-orcid":false,"given":"Ali","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-5924","authenticated-orcid":false,"given":"Fakhar","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Noreen","sequence":"additional","affiliation":[{"name":"Department of Home Economics Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Home Science Chaman Lal Mahavidyalay Landhora  Haridwar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Asif","family":"Shah","sequence":"additional","affiliation":[{"name":"University Center for Research &amp; Development Chandigarh University  Gharuan, Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-2233","authenticated-orcid":false,"given":"Yuosra","family":"Amer\u00a0Ali","sequence":"additional","affiliation":[{"name":"Department of Food Sciences, College of Agriculture and Forestry University of Mosul  Mosul Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"issue":"8","key":"e_1_2_12_2_1","first-page":"8979","article-title":"Nutritional management of PCOS: A review article","volume":"6","author":"Ajith D. 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