{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:02:52Z","timestamp":1790935372042,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["20201203B175"],"award-info":[{"award-number":["20201203B175"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A polysaccharide LDOP\u2010A with a molecular weight of 9.9\u2009kDa was isolated and purified from\n                    <jats:italic>Dendrobium officinale<\/jats:italic>\n                    leaves by membrane separation, cellulose column, and dextran gel column. The Smith degradable products, methylation products, and nuclear magnetic resonance analysis showed that LDOP\u2010A may be composed of \u21924)\u2010Glc\u2010(1\u2192, \u21923,6)\u2010Man\u2010(1\u2192, and \u21926)\u2010Glc\u2010(1\u2192sugar residues. In vitro, simulated digestion assays showed that LDOP\u2010A could be partially digested in the stomach and small intestine, and produced a large amount of acetic acid and butyric acid during colonic fermentation. Further cell experiment results illustrated that LDOP\u2010A\u2010I (LDOP\u2010A digested by gastrointestinal tract) could induce glucagon\u2010like peptide\u20101 (GLP\u20101) secretion in NCI\u2010H716 cells without showing any cytotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.3341","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T14:09:26Z","timestamp":1680271766000},"page":"2686-2696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Physicochemical property changes of\n                    <i>Dendrobium officinale<\/i>\n                    leaf polysaccharide\n                    <scp>LDOP\u2010A<\/scp>\n                    and it promotes\n                    <scp>GLP<\/scp>\n                    \u20101 secretion in\n                    <scp>NCI\u2010H716<\/scp>\n                    cells by simulated saliva\u2010gastrointestinal digestion"],"prefix":"10.1002","volume":"11","author":[{"given":"Jingfang","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Geriatrics Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Zhejiang University of Technology  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongya","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-1761","authenticated-orcid":false,"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.02.034"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b03505"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u20100433\u20109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131294"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07335-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.05.079"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116326"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12663"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0155"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.11541"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.01.009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12808"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00111"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1375576"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.106577"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109888"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2022.100235"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115028"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c02058"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104310"},{"key":"e_1_2_11_23_1","first-page":"670","article-title":"Antioxidant and anti\u2010hyperglycemic activity of polysaccharide isolated from dendrobium chrysotoxum Lindl","volume":"40","author":"Zhao Y.","year":"2007","journal-title":"Journal of Biochemistry Molecular Biology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14023"},{"key":"e_1_2_11_25_1","first-page":"795","article-title":"Comparison on polysaccharide content and PMP\u2010HPLC fingerprints of polysaccharide in stems and leaves of Dendrobium officinale","volume":"39","author":"Zhou G. 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