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Therefore, the purpose of this study was to identify metabolites at different steps of ultra\u2010high\u2010temperature\u2010sterilized (UHT) milk processing using gas chromatography\u2013mass spectrometry (GC\u2013MS). These steps included raw milk, pasteurized milk (80\u00b0C for 15\u2009s), semi\u2010finished milk (after pasteurizing, it was homogenized at 75\u00b0C with pressure of 250\u2009bar), UHT milk (at 140\u00b0C for 10\u2009s), and finished milk (homogenized UHT milk). A total of 66 metabolites were identified across all samples, including 30 metabolites in the chloroform layers of the milk samples and 41 metabolites in the water layers; 5 metabolites were found in both layers. The metabolites were primarily fatty acids, amino acids, sugars, and organic acids. For example, pasteurized and ultra\u2010high\u2010temperature\u2010sterilized kinds of milk had lactose contents similar to those of raw milk, with increases in saturated fatty acids such as hexadecanoic acid and octadecanoic acid. Additionally, these findings indicated that these methods of processing can affect the contents of some components of milk. Therefore, from the perspective of milk's nutritional value and consumer health, the excessive heating of dairy products should be avoided and the milk heat treatment process should be standardized from the source.<\/jats:p>","DOI":"10.1002\/fsn3.3350","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T04:40:19Z","timestamp":1680842419000},"page":"3601-3615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of ultra\u2010high\u2010temperature processes on metabolite changes in milk"],"prefix":"10.1002","volume":"11","author":[{"given":"Ge","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, JLAU\u2010Borui Dairy Science and Technology R&amp;D Center, College of Animal Science and Technology Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-438X","authenticated-orcid":false,"given":"Long","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, JLAU\u2010Borui Dairy Science and Technology R&amp;D Center, College of Animal Science and Technology Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, JLAU\u2010Borui Dairy Science and Technology R&amp;D Center, College of Animal Science and Technology Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Animal and Veterinary Sciences Jilin Academy of Agricultural Sciences  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-3554","authenticated-orcid":false,"given":"Yuguo","family":"Zhen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, JLAU\u2010Borui Dairy Science and Technology R&amp;D Center, College of Animal Science and Technology Jilin Agricultural University  Changchun China"},{"name":"Postdoctoral Scientific Research Workstation, Feed Engineering Technology Research Center of Jilin Province Changchun Borui Science &amp; Technology Co., Ltd.  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