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In the current study, we reviewed recent findings of the mechanism of sesame and its active compounds of sesamin and sesamolin regulates on atherosclerosis. Sesame can decrease the lipid peroxidation and affect the enzymes, which control the balance of oxidative status in the body. Besides modulating the inflammatory cytokines, sesame regulates the main mediators of the signaling pathways in the process of inflammation, such as prostaglandin E2 (PGE2), nuclear factor kappa light\u2010chain enhancer of activated B cells (NF\u2010kB) and peroxisome proliferator\u2010activated receptor gamma (PPAR\u2010\u03b3). Sesame decreases the growth of different pathogens. It fights against obesity and helps to reduce weight, body mass index (BMI), waist circumference, and lipid count of serum and liver. In addition to lowering fasting blood sugar (FBS), it decreases the hemoglobin A1c (HbA1c) and glucose levels and improves insulin function. With high content of linoleic acid, \u03b1\u2010linolenic acid, and total polyunsaturated fatty acid (PUFA), sesame efficiently controls the blood plasma lipids and changes the lipid profile. In the case of hypertension, it maintains the health of endothelium through multiple mechanisms and conserves the response of the arteries to vasodilation. PUFA in sesame suppresses blood clotting and fibrinogen activity. All the mentioned properties combat atherosclerosis and hardening of blood vessels, which are detailed in the present review for sesame.<\/jats:p>","DOI":"10.1002\/fsn3.3407","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T11:25:10Z","timestamp":1684754710000},"page":"3729-3757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Effects of sesame (<i>Sesamum indicum<\/i> L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review"],"prefix":"10.1002","volume":"11","author":[{"given":"Elham","family":"Hadipour","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science University of Guilan  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad","family":"Emami","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Tayarani\u2010Najaran","sequence":"additional","affiliation":[{"name":"Department of Dental Prosthesis, School of Dentistry Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Tayarani\u2010Najaran","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0131"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03601234.2012.640913"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.06.017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.9734\/JALSI\/2015\/15941"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejb.2017.10184"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2011.652077"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480541003782310"},{"key":"e_1_2_11_9_1","first-page":"21","article-title":"Effects of Sesamum indicum L. on fibrinogen and factor 7 in hypercholesterolemic rabbits","volume":"13","author":"Asgary S.","year":"2011","journal-title":"Journal of Shahrekord Uuniversity of Medical Sciences"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/365892"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90272-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.08.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2018.1500183"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/fst.35320"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91084-H"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.ijnfs.s.2015040201.11"},{"key":"e_1_2_11_17_1","volume-title":"Indo\u2013Asian journal of multidisciplinary research","author":"Bakkir L. 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