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The risk of bias and the quality of the included articles were assessed by Cochrane Collaboration Handbook guidance. The statistical analyses were not conducted because of the heterogeneity of the included studies. Of 3676 identified articles, 11 articles were included in this study. The majority of the included studies were not of high quality. Median progression time and overall survival significantly improved. Additionally, surgical site healing complications and infection rates decreased. There was a significant decrease in perceived stress, sleep disturbance, depression, pain, joint stiffness, and fatigue throughout the intervention. Moreover, omega\u20103 fatty acids consumption significantly increased the total serum omega\u20103, EPA, and DHA, and decreased the omega\u20106: omega\u20103 ratio, total leukocytes, lymphocytes, leptin, and CRP, accordingly. Mild gastrointestinal symptoms were reported in only two studies without clinically relevant adverse events. Omega\u20103 fatty acids may cause improvement in physical, mental, and some inflammatory and metabolic indices during treatment or posttreatment course of breast cancer patients. Due to the possibility of free radical formation, omega\u20103 FAs supplementation and consumption must be done very carefully.<\/jats:p>","DOI":"10.1002\/fsn3.3409","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T02:45:09Z","timestamp":1684809909000},"page":"4355-4371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The effectiveness of omega\u20103 fatty acids on health outcomes in women with breast cancer: A systematic review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7984-5043","authenticated-orcid":false,"given":"Shirin","family":"Osouli\u2010Tabrizi","sequence":"first","affiliation":[{"name":"Department of Midwifery, Faculty of Nursing and Midwifery Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-4172","authenticated-orcid":false,"given":"Amir","family":"Mehdizadeh","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8884-4990","authenticated-orcid":false,"given":"Mina","family":"Naghdi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Midwifery, Faculty of Nursing and Midwifery Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-0999","authenticated-orcid":false,"given":"Zohreh","family":"Sanaat","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-5014","authenticated-orcid":false,"given":"Nafiseh","family":"Vahed","sequence":"additional","affiliation":[{"name":"Research Center for Evidence\u2010based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-4613","authenticated-orcid":false,"given":"Azizeh","family":"Farshbaf\u2010Khalili","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Research Center, Aging Research Institute Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01203"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3033279"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.12.2209"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.10.011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.1085582"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01806148"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605441"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.085"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665113001031"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9075-x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.385"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcp.2019.20.3.911"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.20960\/nh.2338"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS16-P2-11-10"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp305"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.10.1245"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010005\u20109005\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201012\u2010355"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcp.2020.21.2.457"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2493"},{"key":"e_1_2_11_22_1","unstructured":"Higgins J. 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