{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:56:12Z","timestamp":1790924172955,"version":"4.1.0"},"reference-count":145,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy that arises from the dysregulation of cell differentiation, proliferation, and cell death. The risk factors associated with the onset of AML include long\u2010term exposure to radiation and chemicals such as benzene, smoking, genetic disorders, blood disorders, advancement in age, and others. Although novel strategies to manage AML, including a refinement of the conventional chemotherapy regimens, hypomethylating agents, and molecular targeted drugs, have been developed in recent years, resistance and relapse remain the main clinical problems. In this study, three databases, PubMed\/MEDLINE, ScienceDirect, and Google Scholar, were systematically searched to identify various bioactive compounds with antileukemic properties. A total of 518 articles were identified, out of which 59 were viewed as eligible for the current report. From the data extracted, over 60 bioactive compounds were identified and divided into five major groups: flavonoids, alkaloids, organosulfur compounds, terpenes, and terpenoids, and other known and emerging bioactive compounds. The mechanism of actions of the analyzed individual bioactive molecules differs remarkably and includes disrupting chromatin structure, upregulating the synthesis of certain DNA repair proteins, inducing cell cycle arrest and apoptosis, and inhibiting\/regulating Hsp90 activities, DNA methyltransferase 1, and histone deacetylase 1.<\/jats:p>","DOI":"10.1002\/fsn3.3420","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:15:27Z","timestamp":1684152927000},"page":"4191-4210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-0693","authenticated-orcid":false,"given":"Chukwuebuka","family":"Egbuna","sequence":"first","affiliation":[{"name":"Africa Centre of Excellence for Public Health and Toxicological Research (ACE\u2010PUTOR) University of Port Harcourt  Port Harcourt Nigeria"},{"name":"Department of Biochemistry, Faculty of Science University of Port Harcourt  Port Harcourt Nigeria"},{"name":"Department of Biochemistry, Faculty of Natural Sciences Chukwuemeka Odumegwu Ojukwu University  Anambra Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley C.","family":"Patrick\u2010Iwuanyanwu","sequence":"additional","affiliation":[{"name":"Africa Centre of Excellence for Public Health and Toxicological Research (ACE\u2010PUTOR) University of Port Harcourt  Port Harcourt Nigeria"},{"name":"Department of Biochemistry, Faculty of Science University of Port Harcourt  Port Harcourt Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene N.","family":"Onyeike","sequence":"additional","affiliation":[{"name":"Africa Centre of Excellence for Public Health and Toxicological Research (ACE\u2010PUTOR) University of Port Harcourt  Port Harcourt Nigeria"},{"name":"Department of Biochemistry, Faculty of Science University of Port Harcourt  Port Harcourt Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johra","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences Majmaah University  Al Majmaah Saudi\u00a0Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-9369","authenticated-orcid":false,"given":"Santwana","family":"Palai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology &amp; Toxicology, College of Veterinary Science and Animal Husbandry OUAT  Odisha Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology L.M. 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