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Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. However, these treatment modalities are still insufficient to solve RM. Omega\u20103 fatty acids are reported to modulate the dysregulation of immune cells, oxidative stress, endocrine disorders, inflammation, etc., which are closely associated with the pathogenesis of RM. However, there is a lack of a systematic description of the involvement of omega\u20103 fatty acids in treating RM, and the underlying mechanisms are also not clear. In this review, we sought to determine the potential mechanisms that are highly associated with the pathogenesis of RM and the regulation of omega\u20103 fatty acids on these mechanisms. In addition, we also highlighted the direct and indirect clinical evidence of omega\u20103 fatty acid supplements to treat RM, which might encourage the application of omega\u20103 fatty acids to treat RM, thus improving pregnancy outcomes.<\/jats:p>","DOI":"10.1002\/fsn3.3464","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T12:03:54Z","timestamp":1685621034000},"page":"4460-4471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Omega\u20103 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence"],"prefix":"10.1002","volume":"11","author":[{"given":"Fangxiang","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huyan","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-374X","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27689"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091413"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.05.068"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8082"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0167482X.2018.1508282"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.12.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2021.10.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038\u2010019\u20100694\u20101"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2012.10.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010015\u20100698\u20103"},{"issue":"11","key":"e_1_2_12_12_1","first-page":"681","article-title":"Overview of omega\u20103 fatty acid therapies","volume":"38","author":"Bradberry J. 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