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Moreover, alcohol drinking may lead to the development of hangover symptoms including diarrhea, thirsty, fatigue, and oxidative stress. A broad range of functional food components with antioxidant and\/or anti\u2010inflammatory properties including pectin, aloe vera polysaccharides, chito\u2010oligosaccharides, and other herbal components have been explored due to their detoxification effects against ethanol. The underlying anti\u2010hangover mechanisms include reducing the intestinal absorption of ethanol or its metabolites, increasing the activity of ethanol metabolizing enzymes, development of fatty acid \u03b2\u2010oxidation in mitochondria, inhibition of inflammatory response, blocking the target receptors of ethanol in the body, and possession of antioxidant activity under the oxidative stress developed by ethanol consumption. Therefore, the development of bioactive food\u2010based therapeutic formula can assist clinicians and also drinkers in the alleviation of alcohol side effects.<\/jats:p>","DOI":"10.1002\/fsn3.3520","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T04:15:37Z","timestamp":1688184937000},"page":"5028-5040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Detoxification activity of bioactive food compounds against ethanol\u2010induced injuries and hangover symptoms: A review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-3329","authenticated-orcid":false,"given":"Masoumeh","family":"Moslemi","sequence":"first","affiliation":[{"name":"Halal Research Center of IRI Ministry of Health and Medical Education  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz","family":"Jannat","sequence":"additional","affiliation":[{"name":"Halal Research Center of IRI Ministry of Health and Medical Education  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mahmoudzadeh","sequence":"additional","affiliation":[{"name":"Nutrition Research Center and Department of Food Science and Technology, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-0878","authenticated-orcid":false,"given":"Mehran","family":"Ghasemlou","sequence":"additional","affiliation":[{"name":"School of Science STEM College, RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdol\u2010Samad","family":"Abedi","sequence":"additional","affiliation":[{"name":"Department of Research Deputy, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2016.10.018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122417"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"927","article-title":"Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats","volume":"31","author":"Ayaz N. 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