{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:42:46Z","timestamp":1778366566664,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["1789"],"award-info":[{"award-number":["1789"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The seeds of <jats:italic>Descurainia sophia<\/jats:italic> (L.) Webb ex Prantl contain goitrogenic glucosinolates, such as gluconapin (3\u2010butenyl glucosinolate). Because of the important role of iodine in the synthesis of thyroid hormones and the inhibitory activity of <jats:italic>D. sophia<\/jats:italic> on iodine uptake by the thyroid gland, this study aimed to determine the effects of <jats:italic>D. sophia<\/jats:italic> syrup on clinical and biochemical variables of thyrotoxicosis in hyperthyroid patients. In this randomized, double\u2010blind trial, 10 newly diagnosed hyperthyroid female patients were randomly assigned to treatment with (1) methimazole (MMI) plus <jats:italic>D. sophia<\/jats:italic> capsules (350\u2009mg\/d) or (2) MMI plus placebo capsules. The primary outcomes were clinical and biochemical manifestations of hyperthyroidism after 60\u2009days. Serum levels of FT3 and FT4 significantly decreased (5.9\u2009\u00b1\u20092.5 vs. 9.4\u2009\u00b1\u20095.9 and 29.1\u2009\u00b1\u20093.1 vs. 31.77\u2009\u00b1\u20093.7, respectively) and the serum thyroid\u2010stimulating hormone (TSH) concentration significantly increased in the <jats:italic>D. sophia<\/jats:italic> group contrasted to the placebo group (4.7\u2009\u00b1\u20090.1 vs. 0.05\u2009\u00b1\u20090.02). Significant improvement in the thyrotoxicosis clinical symptoms was reported in the <jats:italic>D. sophia<\/jats:italic> group contrasted to the placebo group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). <jats:italic>D. sophia<\/jats:italic> can suppress plasma levels of FT3 and FT4 and may be useful as adjunctive therapy for hyperthyroidism.<\/jats:p>","DOI":"10.1002\/fsn3.3522","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T08:40:31Z","timestamp":1688460031000},"page":"5918-5927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the therapeutic effect of <i>Descurainia sophia<\/i> (L.) Webb ex Prantl seed extract on hyperthyroidism: A double\u2010blind placebo\u2010controlled pilot clinical trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Fatemeh","family":"Farzameh","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Azadbakht","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-1323","authenticated-orcid":false,"given":"Zahra","family":"Kashi","sequence":"additional","affiliation":[{"name":"Diabetes Research Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Asgarirad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Salehifar","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Mirzaee","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Davoodi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Medicinal Plants Research Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shervin","family":"Amirkhanloo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00269894"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases4020022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7747"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2495"},{"issue":"3","key":"e_1_2_12_6_1","article-title":"Iodine, thiocyanate and the thyroid","volume":"4","author":"Chandra A.","year":"2015","journal-title":"Biochemistry & Pharmacology: Open Access"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/379458a0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00278-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2298\/FUPCT1702095D"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.04.017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13007-017-0164-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv110"},{"issue":"5","key":"e_1_2_12_14_1","first-page":"575","article-title":"Diagnosis and management of Graves' disease","volume":"168","author":"Ginsberg J.","year":"2003","journal-title":"CMAJ"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-015-2693-5"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"1","article-title":"Starting dose calculation for medicinal plants in animal studies; recommendation of a simple and reliable method","volume":"5","author":"Hosseini A.","year":"2018","journal-title":"Research Journal of Pharmacognosy"},{"key":"e_1_2_12_17_1","volume-title":"Indian pharmacopoeia","author":"Indian Pharmacopoeia Commission","year":"2014"},{"key":"e_1_2_12_18_1","article-title":"Natural products sources and their active compounds on disease prevention: A","volume":"6","author":"Jabeena S.","year":"2014","journal-title":"Health"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9906026"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)00122-5"},{"issue":"1","key":"e_1_2_12_21_1","first-page":"45","article-title":"Descurainia sophia (L.): A weed with multiple medicinal uses","volume":"27","author":"Khan M.","year":"2012","journal-title":"Punjab University Journal of Zoology"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"169","article-title":"Cytotoxic evaluation of volatile oil from Descurainia sophia seeds on MCF\u20107 and HeLa cell lines","volume":"10","author":"Khodarahmi E.","year":"2015","journal-title":"Research in Pharmaceutical Sciences"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781845932732.0453"},{"issue":"2","key":"e_1_2_12_24_1","first-page":"225","article-title":"Studies on the antithyroid activity of naturally occurring L\u20105\u2010vinyl\u20102\u2010thiooxazolidone in man","volume":"57","author":"Langer P.","year":"1971","journal-title":"Endokrinologie"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.08.019"},{"key":"e_1_2_12_26_1","first-page":"399","volume-title":"Physical pharmacy","author":"Martin A.","year":"1983"},{"key":"e_1_2_12_27_1","first-page":"172","volume-title":"Khakshir. Maaref giahi (plant knowledge)","author":"Mirheidar H.","year":"2005"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.01.011"},{"issue":"1","key":"e_1_2_12_29_1","first-page":"58","article-title":"Chemical constituents of Descurainia sophia L. and its biological activity","volume":"3","author":"Mohamed N. H.","year":"2009","journal-title":"Records of Natural Products"},{"key":"e_1_2_12_30_1","first-page":"9","article-title":"Anti\u2010toxoplasma activities of the hydroalcoholic extract of some brassicaceae species. Advanced","volume":"9","author":"Montazeri M.","year":"2020","journal-title":"Biomedical Research"},{"key":"e_1_2_12_31_1","article-title":"Natural products as reservoirs of novel therapeutic agents","volume":"17","author":"Mushtaq S.","year":"2018","journal-title":"EXCLI Journal"},{"issue":"3","key":"e_1_2_12_32_1","first-page":"266","article-title":"Phytochemical and pharmacological aspects of Descurainia sophia Webb ex Prantl: Modern and traditional applications","volume":"6","author":"Nimrouzi M.","year":"2016","journal-title":"Avicenna Journal of Phytomedicine"},{"issue":"6","key":"e_1_2_12_33_1","first-page":"1516","article-title":"A prospective randomized trial of antithyroid drug dose in Graves' disease therapy. European multicenter study group on antithyroid drug treatment","volume":"76","author":"Reinwein D.","year":"1993","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61837-1"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2010-176970"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"issue":"3","key":"e_1_2_12_37_1","first-page":"2014","article-title":"Comparative study of Flixweed properties from the perspective of traditional medicine scientists","volume":"7","author":"Shakeri T.","year":"2017","journal-title":"Complementary Medicine Journal"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.23.17"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0364"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-017-1947-x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.18"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/169194"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.1012"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2006.03.003"},{"key":"e_1_2_12_45_1","volume-title":"28th Asian Edn, Rockvilne","author":"United States Pharmacopoeia","year":"2005"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.010506.103810"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460613"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/952352"},{"issue":"2","key":"e_1_2_12_49_1","article-title":"Chinese herbal medicines for hyperthyroidism","author":"Zeng X.","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"33","key":"e_1_2_12_50_1","article-title":"Determination of trace elements in Descurainia sophia by FAAS","volume":"35","author":"Zhongfeng X.","year":"2007","journal-title":"Journal of Anhui Agricultural Sciences"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:11:03Z","timestamp":1712322663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.3522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/fsn3.3522"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.3522","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"2022-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}