{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:23:11Z","timestamp":1789662191573,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Ficus dicranostyla<\/jats:italic> is a plant from the Moraceae family commonly used in African countries for its nutritional value and its believed medicinal properties. Its antioxidant in vitro capacity and its richness in phenolic compounds have been previously demonstrated. This work aimed at evaluating the hepatoprotective and in vivo antioxidant activities of different granulometric fractions of the <jats:italic>F.\u2009dicranostyla<\/jats:italic> leaves against carbon tetrachloride\u2010induced hepatotoxicity in rats. Powdery fractions (&lt;125, 250\u2013125, and \u2265250\u2009\u03bcm), and the unsieved powder, obtained from the <jats:italic>F.\u2009dicranostyla<\/jats:italic> leaves were water\u2010dissolved and given orally to rats at the same dose (250\u2009mg\/kg body weight) before administering carbon tetrachloride intraperitoneally (1\u2009mL\/Kg bw). The lipid status parameters (total cholesterol, triglycerides, HDL\u2010cholesterol, and LDL\u2010cholesterol), hepatic toxicity through aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) in blood plasma, and antioxidant status by measuring the malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) in liver homogenate were performed. The activities of all parameters registered a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) alteration in CCl<jats:sub>4<\/jats:sub>\u2010treated rats, which were significantly recovered toward an almost normal level in coadministered with <jats:italic>Ficus dicranostyla<\/jats:italic> leaf powder samples in a particle size\u2010dependent manner. Results suggest that the smaller particle size of the powder fraction, as well as the decoction powder of <jats:italic>Ficus dicranostyla,<\/jats:italic> may be used as hepatoprotective and antioxidant agents.<\/jats:p>","DOI":"10.1002\/fsn3.3582","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:25:10Z","timestamp":1692775510000},"page":"6403-6412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatoprotective and in vivo antioxidant effects of granulometric classes and decoction of <i>Ficus dicranostyla<\/i> Mildbread leaves powders against carbon tetrachloride\u2010induced hepatotoxicity in Wistar rats"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-6888","authenticated-orcid":false,"given":"Yves","family":"Tabi\u00a0Omgba","sequence":"first","affiliation":[{"name":"Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-6105","authenticated-orcid":false,"given":"Marthe Valentine","family":"Tsague","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-6332","authenticated-orcid":false,"given":"Romeo Jo\u00ebl","family":"Temdie\u00a0Guemmogne","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4714","authenticated-orcid":false,"given":"Achick Estella","family":"Tembe","sequence":"additional","affiliation":[{"name":"Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-759X","authenticated-orcid":false,"given":"Rose","family":"Ngono\u00a0Mballa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Traditional Medicine, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-9155","authenticated-orcid":false,"given":"Ntungwen Charles","family":"Fokunang","sequence":"additional","affiliation":[{"name":"Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3668-4593","authenticated-orcid":false,"given":"Bonaventure","family":"Ngadjui\u00a0Tchaleu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences University of Yaounde I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-1181","authenticated-orcid":false,"given":"Th\u00e9ophile","family":"Dimo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Sciences University of Yaounde I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-8428","authenticated-orcid":false,"given":"Judith","family":"Ndongo\u00a0Embola","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences\/Biochemistry, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-5848","authenticated-orcid":false,"given":"Jacqueline","family":"Ze\u00a0Minkande","sequence":"additional","affiliation":[{"name":"Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713498448"},{"key":"e_1_2_12_3_1","unstructured":"Baudelaire E.(2013).Commination and controlled differential screening method for the dry extraction of natural active principles. 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