{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:42:18Z","timestamp":1772210538408,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cranberry offers numerous cardiovascular benefits. According to several studies, this fruit promotes the oxidation of low\u2010density lipoprotein, enhances high\u2010density lipoprotein, reduces platelet coagulation, and improves vascular activity. Albino male rats were divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u20095 per group). The control group received intraperitoneal administration of normal saline. The second group was injected with metaproterenol (MET) 3\u2009days a week for 4\u2009weeks. The third, fourth, and fifth groups were given cranberry extract in doses of 75, 100, and 150, respectively, along with heart\u2010damaging drugs. Blood samples were collected and sent to the laboratory on the fourth weekend and 1\u2009week after completing the injections in the fourth week (the sixth weekend) for analyzing serum factors such as cardiac creatine kinase MB, cardiac troponin I (cTnI), and aspartate aminotransferase (AST). The serum activity of the cardiac evaluation parameters in the fourth week demonstrated a highly significant correlation among the groups with respect to AST and cTnI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Additionally, a significant relationship was observed between AST and cTnI within the target groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Ultimately, the findings indicated that the consumption of cranberry extract, due to its impact on heart function, could effectively modify serum indicators associated with heart damage. The utilized extract also exhibited efficacy, albeit with variable effects. Therefore, it is recommended to use cranberry extract synergistically with other chemical and herbal medications to achieve more sustained effects.<\/jats:p>","DOI":"10.1002\/fsn3.3616","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:19:49Z","timestamp":1691644789000},"page":"6670-6675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of alcohol extract of cranberry in improving serum indices of experimental metaproterenol\u2010induced heart damage in rats"],"prefix":"10.1002","volume":"11","author":[{"given":"Kimia","family":"Salmasi","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Tabriz Medical Science Branch Islamic Azad University  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-8152","authenticated-orcid":false,"given":"Ali","family":"Hassanpour","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Science Branch Islamic Azad University  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Amouoghli\u00a0Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Science Branch Islamic Azad University  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine University of Tehran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.10.054"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2061-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100920"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.10.0014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.11.015"},{"issue":"5","key":"e_1_2_12_7_1","first-page":"353","article-title":"Enzymatic diagnosis of alcoholism\u2010induced damage of internal organs","volume":"23","author":"Chrostek L.","year":"1989","journal-title":"Psychiatr Polska"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.11.1173"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109056"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024115714236"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.21608\/zvjz.2021.55792.1132"},{"issue":"17","key":"e_1_2_12_12_1","first-page":"4049","article-title":"Cardioprotective effects of Curcuma longa L. extracts against doxorubicin\u2010induced cardiotoxicity in rats","volume":"5","author":"Eman M. 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