{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:41Z","timestamp":1791919541892,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["No: 2019KZDZX2003 and 2020KZDZX1203"],"award-info":[{"award-number":["No: 2019KZDZX2003 and 2020KZDZX1203"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901678"],"award-info":[{"award-number":["81901678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Niudali (<jats:italic>Callerya speciosa<\/jats:italic>) is commonly grown in southeastern regions of China and consumed as a food ingredient. Although Niudali root extracts showed various biological activities, the hepatoprotective effects of Niudali root phytochemicals are not fully studied. Herein, we prepared two Niudali root aqueous extracts, namely, c and Niudali polysaccharides\u2010enriched extract (NPE), and identified an alkaloid, (hypaphorine) in NEW. The hepatoprotective effects of NWE, NPE, and hypaphorine were evaluated in an acute liver injury model induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) in mice. Pathohistological examination and blood chemistry assays showed that treatment of NWE, NPE, and hypaphorine alleviated CCl<jats:sub>4<\/jats:sub>\u2010induced liver damage by lowering the liver injury score (by 75.51%, 80.01%, and 41.22%) and serum aspartate and alanine transaminases level (by 63.24%, 85.22%, and 49.74% and by 78.73%, 80.08%, and 81.70%), respectively. NWE, NPE, and hypaphorine also reduced CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic oxidative stresses in the liver tissue by decreasing the levels of malondialdehyde (by 40.00%, 51.25%, and 28.75%) and reactive oxygen species (by 30.22%, 36.14%, and 33.54%) while increasing the levels of antioxidant enzymes including superoxide dismutase (by 21.36%, 21.64%, and 8.90%), catalase (by 22.13%, 33.33%, and 5.39%), and glutathione (by 84.87%, 90.65%, and 80.53%), respectively. Mechanistic assays showed that NWE, NPE, and hypaphorine alleviated liver damage by mediating inflammatory biomarkers (e.g., pro\u2010inflammatory cytokines) via the signaling pathways of mitogen\u2010activated protein kinases and nuclear factor\u2010\u03baB. Findings from our study extend the understanding of Niudali's hepatoprotective effects, which is useful for its development as a dietary intervention for liver inflammation.<\/jats:p>","DOI":"10.1002\/fsn3.3626","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:37:30Z","timestamp":1692653850000},"page":"7026-7038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatoprotective effects of Niudali (<i>Callerya speciosa<\/i>) root aqueous extracts against tetrachloromethane\u2010induced acute liver injury and inflammation"],"prefix":"10.1002","volume":"11","author":[{"given":"Yizi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishe","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"},{"name":"International Healthcare Innovation Institute (Jiangmen)  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihui","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"},{"name":"International Healthcare Innovation Institute (Jiangmen)  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"},{"name":"International Healthcare Innovation Institute (Jiangmen)  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghan","family":"Wang","sequence":"additional","affiliation":[{"name":"Bioactive Botanical Research Laboratory, Biomedical and Pharmaceutical Sciences, College of Pharmacy University of Rhode Island  Kingston Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-1185","authenticated-orcid":false,"given":"Shili","family":"Sun","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation &amp; Utilization  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation &amp; Utilization  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Microbial Pharmaceuticals, College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Health Sciences Wuyi University  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Sun","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation &amp; 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