{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:06Z","timestamp":1787068266784,"version":"build-2736575974"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    is a medicinal plant that has anti\u2010inflammatory, antihypertensive, antidiabetic, tissue\u2010protective, and antioxidant activities. Here, we evaluated the protective effect of\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    leaf powder (MoLP) and 70% ethanol\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    leaf extract (MoLE) on mitigating polycystic ovary syndrome (PCOS)\u2010induced liver and kidney dysfunction via regulating oxidative stress in female albino mice (\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    ). The efficacy of\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    was compared with metformin (standard medicine used to treat infertility in women). PCOS was induced by intramuscular injection of testosterone enanthate at 1.0\u2009mg\/100\u2009g BW for 35\u2009days. PCOS\u2010induced mice were treated with MoLP (250 and 500\u2009mg\/Kg), MoLE (250 and 500\u2009mg\/kg), and metformin (250\u2009mg\/kg) orally for 14\u2009days. Renal function test (RFT), liver function test (LFT), and oxidative stress biomarker malondialdehyde (MDA) were quantified in serum at 0, 7, and 14\u2009days of intervention. Mice treated with\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    and metformin showed a significant decrease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphate (ALP), total bilirubin, urea, creatinine, and a significant increase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) in total protein, albumin, globulin, and albumin\/globulin (A\/G) ratio. Oxidative stress decreased significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.00) with respect to treatments, exposure days, and their interaction in metformin and all\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    \u2010treated groups.\n                    <jats:italic>M.\u2009oleifera<\/jats:italic>\n                    leaf powder and extract reduce oxidative stress and enhance nephron\u2010hepatic activity in PCOS\u2010induced female albino mice.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.3646","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:53:36Z","timestamp":1693616016000},"page":"7206-7217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of hepatoprotective, nephroprotective efficacy, and antioxidative potential of\n                    <i>Moringa oleifera<\/i>\n                    leaf powder and ethanolic extract against\n                    <scp>PCOS<\/scp>\n                    \u2010induced female albino mice (\n                    <i>Mus Musculus<\/i>\n                    )"],"prefix":"10.1002","volume":"11","author":[{"given":"Shakeela","family":"Khalid","sequence":"first","affiliation":[{"name":"Department of Zoology University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Zoology University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Raza","sequence":"additional","affiliation":[{"name":"Liver Center District Headquarter Hospital  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Nutrition University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-2494","authenticated-orcid":false,"given":"Farzana","family":"Siddique","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Nutrition University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Zoology University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarfraz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Air Base College  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Khalid","sequence":"additional","affiliation":[{"name":"University Institute of Food Science and Technology The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"AL\u2010Farga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Sciences University of Jeddah  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-3262","authenticated-orcid":false,"given":"Faisal","family":"Aqlan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Sciences Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145083"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903410354"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"1","article-title":"Protective effect of carvacrol on renal functional and histopathological changes in gentamicin\u2010induced\u2010nephrotoxicity in rats","volume":"18","author":"Ahmadvand H.","year":"2016","journal-title":"Zahedan Journal of Research in Medical Sciences"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10040626"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S160537"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"110","article-title":"Moringa oleifera ameliorates nephropathic changes in alloxaninduced diabetic adult Wistar rats","volume":"6","author":"Akpan H. 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