{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:23:19Z","timestamp":1785165799304,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal hypoxic\u2010ischemic brain damage (HIBD) is a leading cause of infant mortality worldwide. This study explored whether quercetin (Que) exerts neuroprotective effects in a rat model of HIBD. A total of 36 seven\u2010day\u2010old Sprague\u2013Dawley rats were divided into control, Que, HI, and HI\u2009+\u2009Que groups. The Rice method was used to establish HIBD in HI and HI\u2009+\u2009Que rats, which were treated with hypoxia (oxygen concentration of 8%) for 2\u2009h after ligation of the left common carotid artery. The rats in the HI\u2009+\u2009Que group were intraperitoneally injected with Que (30\u2009mg\/kg) 1\u2009h before hypoxia, and the rats in the Que group were only injected with the same amount of Que. Brain tissues were harvested 24\u2009h postoperation and assessed by hematoxylin and eosin staining, 2,3,5\u2010triphenyltetrazolium chloride staining, and terminal deoxynucleotidyl transferase dUTP nick\u2010end labeling assay; relative gene and protein levels were evaluated by RT\u2010qPCR, IHC, or western blot (WB) assay. Brain tissue morphologies were characterized by transmission electron microscopy (TEM); LC3B protein levels were assessed by immunofluorescence staining. Escape latencies and platform crossing times were significantly improved (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) in HI\u2009+\u2009Que groups; infarct volume significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), whereas the numbers of autophagic bodies and apoptotic cells increased and decreased, respectively. Meanwhile, NLRX1, ATG7, and Beclin1 expressions were significantly upregulated, and mTOR and TIM23 expressions, LC3B protein level, and LC 3II\/LC 3I ratio were significantly downregulated. Que exerted neuroprotective effects in a rat model of HIBD by regulating NLRX1 and autophagy.<\/jats:p>","DOI":"10.1002\/fsn3.3684","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:16:00Z","timestamp":1697184960000},"page":"7649-7663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protective mechanisms of quercetin in neonatal rat brain injury induced by <scp>hypoxic\u2010ischemic<\/scp> brain damage (<scp>HIBD<\/scp>)"],"prefix":"10.1002","volume":"11","author":[{"given":"Yan\u2010hong","family":"Xu","sequence":"first","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6682-3508","authenticated-orcid":false,"given":"Guang\u2010lei","family":"Tong","sequence":"additional","affiliation":[{"name":"Anhui Provincial Children's Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0503-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12353"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4248529"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236093"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13590"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.08.026"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0916-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12971"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000451"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00097.2010"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70261-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13560"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3554"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3444-3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040898"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43441"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.06.018"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.025"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2005.8.3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.3796"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12986"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.08.012"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06501"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02419"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.056"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6303-11.2012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2016.08.003"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01764-x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13291"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00417"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133177"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14821"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.018"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161031"},{"issue":"11","key":"e_1_2_11_41_1","first-page":"14701","article-title":"Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic\u2010ischemic brain damage","volume":"8","author":"Sun M. Y.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2599-3"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700251"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12943"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.06.011"},{"key":"e_1_2_11_46_1","first-page":"5521","article-title":"Plant\u2010derived nootropics and human cognition: A systematic review","volume":"63","author":"Vilella E.","year":"2022","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176448"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09673-5"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.12.008"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1259567"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591815"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.25132"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-021-00377-3"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0324-2"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2618-4"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2808"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7120229"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718947"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:44:49Z","timestamp":1744224289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.3684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/fsn3.3684"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.3684","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"2023-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}