{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:06:13Z","timestamp":1773317173820,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["95\u201004\u201027\u201030284"],"award-info":[{"award-number":["95\u201004\u201027\u201030284"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that hesperidin may have beneficial effects on depression; however, to the best of our knowledge, no clinical trial has yet been conducted in this area. The aim of the present study was, therefore, to determine the effects of hesperidin on depression, serum brain\u2010derived neurotrophic factor (BDNF), and serum cortisol levels in post\u2010coronary artery bypass graft (CABG) patients. Toward this goal, 73 post\u2010CABG patients with depression symptoms were enrolled. The participants were randomly divided into two groups to receive either 200\u2009mg\/day hesperidin (<jats:italic>n<\/jats:italic>\u2009=\u200938) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200935) for 12\u2009weeks. Depressive symptoms, serum BDNF, and cortisol levels were then assessed at the baseline and after intervention. Beck Depression Inventory\u2010II (BDI\u2010II) was also used to determine the severity of depression. Sixty\u2010six patients completed the trial. Hesperidin decreased depression severity after 12\u2009weeks, as compared to placebo (<jats:italic>p<\/jats:italic>\u2009=\u2009.004), but serum BDNF and cortisol were not statistically significantly different in the two groups after the intervention. Subgroup analyses also showed that, while in the patients with mild depression, the score of BDI\u2010II was significantly different in the hesperidin and placebo groups after intervention; there was no difference in the severity of depression between the two groups in patients with moderate\u2010to\u2010severe depression. To conclude, a dose of 200\u2009mg\/day hesperidin may reduce depressive symptoms after 12\u2009weeks in post\u2010CABG patients with mild depression.<\/jats:p>","DOI":"10.1002\/fsn3.3692","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:56:57Z","timestamp":1695970617000},"page":"7742-7750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hesperidin reduces depressive symptoms in post\u2010coronary artery bypass graft patients with mild depression"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-4936","authenticated-orcid":false,"given":"Atie Sadat","family":"Khorasanian","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-4209","authenticated-orcid":false,"given":"Shima","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"},{"name":"Research Center for Prevention of Cardiovascular Disease Institute of Endocrinology &amp; Metabolism, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-1661","authenticated-orcid":false,"given":"Negar","family":"Omidi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-650X","authenticated-orcid":false,"given":"Zahra","family":"Booyani","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-9430","authenticated-orcid":false,"given":"Mehrnaz","family":"Morvaridi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5800-2338","authenticated-orcid":false,"given":"Mehdi","family":"Tehrani\u2010Doost","sequence":"additional","affiliation":[{"name":"Department of Research Center for Cognitive and Behavioral Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8994","authenticated-orcid":false,"given":"Agha Fateme","family":"Hoseini","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-2955","authenticated-orcid":false,"given":"Mostafa","family":"Nejatian","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-8561","authenticated-orcid":false,"given":"Naheed","family":"Aryaeian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912-022-00857-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.06.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.07.042"},{"key":"e_1_2_11_5_1","first-page":"133","article-title":"Diagnostic and statistical manual of mental disorders","volume":"17","author":"Association, A. P","year":"2013","journal-title":"BMC Medicine"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3187"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.09.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.6.464"},{"issue":"2","key":"e_1_2_11_10_1","first-page":"229","article-title":"Effect of hesperidin on behavior and HPA axis of rat model of chronic stress\u2010induced depression","volume":"38","author":"Cai L.","year":"2013","journal-title":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China Journal of Chinese Materia Medica"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01916-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06803-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.3.0012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.03.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.0074"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0281"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.718S"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.03.035"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1074"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20070"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0578-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3083"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000174046.40566.80"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)70964-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.08.024"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/62891"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.20.8060"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9860-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.040"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.03.016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116686883"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030329"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181e6df90"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00071-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9828639"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.09.008"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5256"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.06.006"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.03.012"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2005.12.009"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/24426"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0975"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2004.09.001"},{"key":"e_1_2_11_46_1","volume-title":"Depression: questions you have\u2010answers you need","author":"Salmans S.","year":"1995"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.09.003"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oeac015"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170718104412"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1525-1"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf2040675"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2098"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000352"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:46:15Z","timestamp":1744224375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.3692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/fsn3.3692"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.3692","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"2023-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}