{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:58:32Z","timestamp":1768683512844,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnancy dramatically changes maternal metabolism and the microbiome. Low\u2010grade inflammation can cause maternal complications and fetal abnormalities. The objective of this open\u2010label, randomized, controlled study was to evaluate the efficacy and safety of orally administered <jats:italic>Chlorella<\/jats:italic>, a green alga that is commercially available as a dietary supplement with rich nutrients and dietary fiber for pregnant women with low\u2010grade inflammation. Patients with C\u2010reactive protein levels &gt;0.05\u2009mg\/dL (16\u2009weeks gestation, <jats:italic>n<\/jats:italic>\u2009=\u200922) were enrolled and randomly allocated to the <jats:italic>Chlorella<\/jats:italic> group (<jats:italic>n<\/jats:italic>\u2009=\u200910) or control group (<jats:italic>n<\/jats:italic>\u2009=\u200912). We conducted blood biochemical tests at 25, 30, and 35\u2009weeks gestation and evaluated the evacuation status (symptoms depending on the Rome IV C2 criteria and laxative usage), side effects, and complications throughout the investigation. We also monitored the status of the offspring. The <jats:italic>Chlorella<\/jats:italic> group (<jats:italic>n<\/jats:italic>\u2009=\u20090) showed a significantly lower rate of constipation than the control group (<jats:italic>n<\/jats:italic>\u2009=\u20098). This study demonstrated the beneficial effects and safety of <jats:italic>Chlorella<\/jats:italic> supplementation in pregnant women, which prevented constipation and unnecessary laxative administration.<\/jats:p>","DOI":"10.1002\/fsn3.3759","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:50:08Z","timestamp":1697442608000},"page":"292-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of <i>Chlorella<\/i> supplementation in pregnant women with low\u2010grade inflammation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-9614","authenticated-orcid":false,"given":"Yoko","family":"Uchiyama\u2010Tanaka","sequence":"first","affiliation":[{"name":"Yoko Clinic  Kitakyushu, Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Shimabukuro","sequence":"additional","affiliation":[{"name":"Yui Clinic  Noborikawa Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Okumura","sequence":"additional","affiliation":[{"name":"Sun Chlorella Corp  Kyoko Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Sun Chlorella Corp  Kyoko Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8121996"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061273"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.712614"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030452"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.004"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd001142"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.005"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11050725"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00087"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20100528.1998.tb10123.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.62.873"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.0180"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.023"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010009\u20100145\u20109"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.648073"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180874"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053785"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20100528.2000.tb11608.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082330"},{"key":"e_1_2_13_22_1","first-page":"1411","article-title":"Constipation, haemorrhoids, and heartburn in pregnancy","volume":"2010","author":"Vazquez J. 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