{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:40:03Z","timestamp":1747219203712,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes mellitus unbalances cellular antioxidant levels. This phenomenon can potentially lead to cellular damage and apoptosis in the male reproductive system. Besides, herbal\u2010based antioxidants can prevent these detrimental changes. Thus, we assessed the probable role of Aubergine stems with antioxidant and anti\u2010hyperlipidemic characteristics on reproductive damage following diabetes mellitus induction. Forty male NMRI mice were categorized into groups of control and treatments. Diabetes was induced by a single dose of streptozotocin (60\u2009mg\/kg), and the extract was administered at various doses (100, 300, and 500\u2009mg\/kg) daily for 4\u2009weeks. Antioxidative features of the extract were approved by phytochemical assays and ferric\u2010reducing ability of plasma. Side\u2010effects of diabetes were also assessed by the malondialdehyde (MDA) and Griess techniques. Sperm parameters, LH, FSH, and testosterone levels, the TUNEL assay, histopathologic alteration, and apoptotic genes (p53, caspase\u20103, Bcl\u20102) were evaluated. Results showed that diabetes increased oxidation levels and the extract accelerated total antioxidant capacity status. Sperm parameters and hormone levels were restored following extract administration in diabetic animals. Also, the apoptosis rate decreased following extract administration in diabetic animals. We concluded that diabetes can elevate the levels of oxidation and suppress the antioxidant power. These pathologic changes were restored by Aubergine stem, leading to decreased levels of apoptosis and normal serum levels of testosterone, LH, and FSH.<\/jats:p>","DOI":"10.1002\/fsn3.3767","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T07:39:59Z","timestamp":1697873999000},"page":"399-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aubergine stem restores reproductive damages following diabetes mellitus induction in male mice"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-447X","authenticated-orcid":false,"given":"Parsa","family":"Rostamzadeh","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences, Medical School Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-0919","authenticated-orcid":false,"given":"Vahid","family":"Shokri\u2010Asl","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-8609","authenticated-orcid":false,"given":"Fatemeh Mansouri","family":"Torghabeh","sequence":"additional","affiliation":[{"name":"Department of Physiology Sciences, Medical School Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1354-1151","authenticated-orcid":false,"given":"Samira","family":"Davoudi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-5284","authenticated-orcid":false,"given":"Ahmad","family":"Haghzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry, Tabriz Branch Islamic Azad University  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-6773","authenticated-orcid":false,"given":"Shima","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Medical School Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13126"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913315"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148232"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","unstructured":"Fauziah A. I. Saraswati L. D. Udiyono A. &Safitri B.(2020).The effect of herbal infusion on fasting blood glucose (FBS) and Malondyaldehyde (MDA) levels in diabetic rats. Paper Presented at the Materials Science Forum.","DOI":"10.4028\/www.scientific.net\/MSF.1009.9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.107.002717"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13586"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"Henr\u00edquez C. Carrasco\u2010Pozo C. G\u00f3mez M. Brunser O. &Speisky H.(2008).Slow and fast\u2010reacting antioxidants from berries: Their evaluation through the frap (FERRIC REDUCING antioxidant power) assay.","DOI":"10.17660\/ActaHortic.2008.777.82"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.058"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891\u20105849(95)02043\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.183012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-018-0012-9"},{"key":"e_1_2_11_14_1","unstructured":"Laulloo S. B. J. Bhowon M. 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