{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:40Z","timestamp":1786977820604,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Myo\u2010inositol (MI) is a carbocyclic sugar polyalcohol. MI has known to exert anti\u2010inflammatory, anti\u2010oxidant, and anti\u2010diabetic activities. This study aimed to investigate the effects of MI supplementation on oxidative stress biomarkers in obese patients with non\u2010alcoholic fatty liver disease (NAFLD). In this double\u2010blinded placebo\u2010controlled randomized clinical trial, 51 newly diagnosed obese patients with NAFLD were randomly assigned to receive either MI (4\u2009g\/day) or placebo supplements accompanied by dietary recommendations for 8\u2009weeks. Oxidative stress biomarkers, nutritional status, as well as liver enzymes and obesity indices were assessed pre\u2010 and post\u2010intervention. A total of 48 patients completed the trial. Although anthropometric measures and obesity indices decreased significantly in both groups, the between\u2010group differences adjusted for confounders were non\u2010significant for these parameters, except for weight (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.049); greater decrease was observed in the MI group. Iron and zinc intakes decreased significantly in both groups; however, between\u2010group differences were non\u2010significant at the end of the study. No significant between\u2010group differences were revealed for other antioxidant micronutrients at the study endpoint. Sense of hunger, feeling to eat, desire to eat sweet and fatty foods reduced significantly in both groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05), while the feeling of satiety increased significantly in the placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.002). No significant between\u2010group differences were observed for these parameters, except for desire to eat fatty foods; a greater decrease was observed in the MI group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.034). Serum levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly increased in both study groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05); however, the between\u2010group differences were non\u2010significant at the end of the study. Furthermore, the between\u2010group differences were non\u2010significant for other oxidative stress biomarkers, except for serum nitric oxide (NO) level; a greater decrease was observed in the MI group. MI supplementation could significantly improve weight, desire to eat fatty foods, serum levels of NO, as well as the aspartate aminotransferase (AST)\/ALT ratio.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.3842","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T18:00:28Z","timestamp":1701972028000},"page":"1279-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does myo\u2010inositol supplementation influence oxidative stress biomarkers in patients with non\u2010alcoholic fatty liver disease?"],"prefix":"10.1002","volume":"12","author":[{"given":"Somayeh","family":"Rostami","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition &amp; Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-5571","authenticated-orcid":false,"given":"Sara","family":"Arefhosseini","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition &amp; Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-1757","authenticated-orcid":false,"given":"Helda","family":"Tutunchi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouchehr","family":"Khoshbaten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-1289","authenticated-orcid":false,"given":"Mehrangiz","family":"Ebrahimi\u2010Mameghani","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition &amp; Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080870"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020117-043617"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1092544"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i16.715"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.03.014"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i28.5115"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34168"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215079"},{"key":"e_1_2_12_11_1","unstructured":"Committee I. 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