{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:59:29Z","timestamp":1787763569728,"version":"build-2784847793"},"reference-count":81,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The medicinal potential of <jats:italic>Coelogyne suaveolens<\/jats:italic>, a traditional medicinal plant, was investigated through in\u00a0vivo and molecular docking studies. The ethyl acetate fraction of the plant's acetonic extract was subjected to various bioactivity tests to assess its analgesic, anxiolytic, and sedative effects on Swiss albino mice. Furthermore, we used GCMS to identify the bioactive chemicals in the extract's ethyl acetate fraction. The root and bulb extracts demonstrated significant analgesic activity in acetic acid\u2010induced writhing, hot plate, and tail immersion tests in a dose\u2010dependent manner when compared to the control. Again, the extract exhibited moderate anxiolytic activity in the elevated plus maze test at a dosage of 400\u2009mg\/kg body weight, while the root extract showed significant anxiolytic activity in the hole board test at the same dosage. Significant sedative activity was observed in the hole cross, open field, and rotarod tests at a dosage of 400\u2009mg\/kg. According to molecular docking studies, the extract has the potential to serve as an analgesic medication by reducing the enzymatic activity of cyclooxygenases 1 and 2. Overall, the findings suggest that <jats:italic>C. suaveolens<\/jats:italic> has substantial therapeutic potential for the development of novel treatments for pain, anxiety, and sleep disorders.<\/jats:p>","DOI":"10.1002\/fsn3.3867","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:10:18Z","timestamp":1701994218000},"page":"1749-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Unveiling the pharmacological potential of <i>Coelogyne suaveolens<\/i>: An investigation of its diverse pharmacological activities by in\u00a0vivo and computational studies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-9734","authenticated-orcid":false,"given":"Taslima Akter","family":"Eva","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husnum","family":"Mamurat","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Habibul Hasan","family":"Rahat","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-3257","authenticated-orcid":false,"given":"S. M. Moazzem","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-021-00313-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v9i1.4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10051016"},{"key":"e_1_2_12_5_1","unstructured":"Arunkumar G. Anbarasan B. Murugavel R. 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