{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:57:51Z","timestamp":1773381471605,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The efficacy of administering high doses of vitamin D to patients diagnosed with COVID\u201019 remains uncertain. We conducted a comprehensive search across multiple databases (PubMed, EMBASE, Cochrane Library, and ISI Web of Science) from inception until August 2022, with no limitations on language, to locate randomized controlled trials (RCTs) that investigated the impact of high\u2010dose vitamin D supplementation (defined as a single dose of \u2265100,000\u2009IU or daily dose of \u226510,000\u2009IU reaching a total dose of \u2265100,000\u2009IU) on COVID\u201019 patients. Risk ratios (RR) with 95% confidence intervals (CI) and weighted mean differences (WMD) with 95% CI were calculated. Our meta\u2010analysis included 5 RCTs with a total of 834 patients. High\u2010dose vitamin D supplementation did not show any significant benefits for mortality (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.670; RR 1.092, 95% CI 0.685\u20131.742, <jats:italic>p<\/jats:italic>\u2009=\u2009.711) or intensive care unit (ICU) admission (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.519; RR 0.707, 95% CI 0.454\u20131.102, <jats:italic>p<\/jats:italic>\u2009=\u2009.126) in COVID\u201019 patients compared to the control group. However, it was found to be safe and well\u2010tolerated (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.887; RR 1.218, 95% CI 0.930\u20131.594, <jats:italic>p<\/jats:italic>\u2009=\u2009.151). Subgroup analysis also showed no benefits in overall mortality, including for patients with vitamin D deficiency (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.452; RR 2.441, 95% CI 0.448\u201313.312, <jats:italic>p<\/jats:italic>\u2009=\u2009.303) or compared to the placebo (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.673; RR 1.666, 95% CI 0.711\u20133.902, <jats:italic>p<\/jats:italic>\u2009=\u2009.240). Our research indicates that there is no evidence to support the efficacy of high\u2010dose vitamin D supplementation in improving clinical outcomes among individuals with COVID\u201019, in line with previous studies focused on contexts including rickets. Considering the limitations of the study, additional research may be required.<\/jats:p>","DOI":"10.1002\/fsn3.3875","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T02:07:10Z","timestamp":1702001230000},"page":"1808-1817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High\u2010dose vitamin D supplementation in patients with <scp>COVID<\/scp>\u201019: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhaoshuang","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Respiratory Central Hospital, Shenyang Medical College  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Central Hospital, Shenyang Medical College  Shenyang 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