{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:16:05Z","timestamp":1792120565247,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the beneficial effects of probiotic yogurt on lipid metabolism and gut microbiota in metabolic\u2010related fatty liver disease (MAFLD) golden hamsters fed on a high\u2010fat diet (HFD). The results demonstrated that probiotic yogurt significantly reversed the adverse effects caused by HFD, such as body and liver weight gain, liver steatosis and damage, sterol deposition, and oxidative stress after 8\u2009weeks of intervention. qRT\u2010PCR analysis showed that golden hamsters fed HFD had upregulated genes related to adipogenesis, increased free fatty acid infiltration, and downregulated genes related to lipolysis and very low\u2010density lipoprotein secretion. Probiotic yogurt supplements significantly inhibited HFD\u2010induced changes in the expression of lipid metabolism\u2010related genes. Furthermore, 16S rRNA gene sequencing of the intestinal content microbiota suggested that probiotic yogurt changed the diversity and composition of the gut microbiota in HFD\u2010fed hamsters. Probiotic yogurt decreased the ratio of the <jats:italic>phyla Firmicutes\/Bacteroidetes<\/jats:italic>, the relative abundance of the LPS\u2010producing genus <jats:italic>Desulfovibrio<\/jats:italic>, and bacteria involved in lipid metabolism, whereas it increased the relative abundance of short\u2010chain fatty acids producing bacteria in HFD\u2010fed hamsters. Predictive functional analysis of the microbial community showed that probiotic yogurt\u2010modified genes involved in LPS biosynthesis and lipid metabolism. In summary, these findings support the possibility that probiotic yogurt significantly improves HFD\u2010induced metabolic disorders through modulating intestinal microflora and lipid metabolism and effectively regulating the occurrence and development of MAFLD. Therefore, probiotic yogurt supplementation may serve as an effective nutrition strategy for the treatment of patients with MAFLD clinically.<\/jats:p>","DOI":"10.1002\/fsn3.3930","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T07:05:25Z","timestamp":1704438325000},"page":"2488-2501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Probiotic yogurt regulates gut microbiota homeostasis and alleviates hepatic steatosis and liver injury induced by high\u2010fat diet in golden hamsters"],"prefix":"10.1002","volume":"12","author":[{"given":"Linwensi","family":"Zhu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ying","sequence":"additional","affiliation":[{"name":"School of Life Science Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyi","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Public Health Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Life Science Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinchao","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Science Zhejiang University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiwei","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Public Health Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-0033","authenticated-orcid":false,"given":"Daxi","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Science Zhejiang University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-4682","authenticated-orcid":false,"given":"Qiang","family":"Han","sequence":"additional","affiliation":[{"name":"School of Public Health Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Academy of Chinese Medical Science Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Academy of Chinese Medical Science Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106489"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.057968"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"1","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves\u2010Bezerra M.","year":"2017","journal-title":"Comprehensive Physiology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.01.023"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2947-0"},{"key":"e_1_2_12_7_1","first-page":"195","article-title":"Diet\u2010induced metabolic hamster model of nonalcoholic fatty liver disease","volume":"4","author":"Bhathena J.","year":"2011","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.153197"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328328d0a4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29892"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020096"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy358"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M093112"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1661-0_1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2671-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422417000191"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2019.1571114"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.09.078"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.036"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31897"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.06.023"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i25.2661"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9862"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.06.023"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy056"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303816"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.85"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.10.031"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.11.009"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-3-245"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.153"},{"issue":"2","key":"e_1_2_12_34_1","first-page":"240","article-title":"Nonalcoholic fatty liver disease, the gut microbiome, and diet","volume":"8","author":"Mokhtari Z.","year":"2017","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26319"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102536"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2007.00752.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030494"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091112"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.002683"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030677"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.24"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.014"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.016"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060928"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03011-w"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14711-3"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09512-0"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.007"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00225.2016"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6776"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311000200"},{"issue":"10","key":"e_1_2_12_54_1","article-title":"Mediterranean diet and multi\u2010ingredient\u2010based interventions for the management of non\u2010alcoholic fatty liver disease","volume":"9","author":"Su\u00e1rez M.","year":"2017","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.013"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32002"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030825"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.240754"},{"issue":"1","key":"e_1_2_12_59_1","first-page":"99","article-title":"Differential effects of in\u00a0vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver","volume":"60","author":"Wierzbicki M.","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"2","key":"e_1_2_12_60_1","first-page":"192","article-title":"The gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease","volume":"47","author":"Woodhouse C. A.","year":"2018","journal-title":"Diseases"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15025"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b01082"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.900033"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800018-JLR200"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0542"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i17.2019"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.3930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T01:16:58Z","timestamp":1713143818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.3930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/fsn3.3930"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.3930","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"2023-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}