{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:48:53Z","timestamp":1780577333512,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oregano (<jats:italic>Origanum vulgare<\/jats:italic>) seed is used as spices and is known to have anti\u2010inflammatory, antibacterial, and antioxidant effects. The anti\u2010fatty liver effects of oregano seed ethyl acetate (OSEA) were evaluated in high\u2010fat diet (HFD)\u2010induced obese mice. OSEA was orally administered with HFD for 10\u2009weeks. The body weight, aspartate aminotransferase, alanine aminotransferase, cholesterol, triglyceride, and low\u2010density lipoprotein levels in the HFD with 100\u2009mg\/kg of OSEA significantly decreased by approximately 1.21\u2010, 1.44\u2010, 2.12\u2010, 1.12\u2010, 1.05, and 1.59 times, respectively, while high\u2010density lipoprotein levels increased by approximately 1.05 times compared to those in the HFD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In addition, the distribution of liver fat in the HFD with 100\u2009mg\/kg OSEA (OSEA 100) group decreased significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Therefore, OSEA supplementation can ameliorate fatty liver disease and reduce the accumulation of triglycerides in adipose tissue. The expression of genes involved in liver fat accumulation, such as sterol regulatory element\u2010binding protein\u20101c (<jats:italic>Srebp\u20101c<\/jats:italic>), fatty acid synthase (<jats:italic>Fas<\/jats:italic>), stearoyl\u2010CoA desaturase\u20101 (<jats:italic>Scd1<\/jats:italic>), and acetyl\u2010CoA carboxylase 1 (<jats:italic>Acc1<\/jats:italic>), significantly decreased in OSEA 100 by approximately 2.6\u2010, 1.74\u2010, 1.89\u2010, and 1.56\u2010times, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Therefore, OSEA may modify obesity and liver fat accumulation by regulating the expression of genes involved in lipid metabolism.<\/jats:p>","DOI":"10.1002\/fsn3.3939","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:50:15Z","timestamp":1705405815000},"page":"2578-2587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ethyl acetate fraction of oregano seed protects non\u2010alcoholic fatty liver in high\u2010fat diet\u2010induced obese mice through modulation of <i>Srebp\u20101c<\/i>"],"prefix":"10.1002","volume":"12","author":[{"given":"Hyun\u2010Jong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, College of Health Science Kangwon National University  Samcheok Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Health Science Kangwon National University  Samcheok Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-8384","authenticated-orcid":false,"given":"Mi\u2010Ja","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Health Science Kangwon National University  Samcheok Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.01.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.3601"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.11.016"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"352","article-title":"Antimicrobial effect of oregano (Origanum majorana L.) extract on food\u2010borne pathogens","volume":"21","author":"Choi M. 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