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In 2020, approximately 20 million new cancer cases and 10 million cancer\u2010related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant\u2010derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent\u2010kaurane diterpenoid, naturally found in the leaves of\n                    <jats:italic>Rabdosia rubescens<\/jats:italic>\n                    species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.3986","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:32:21Z","timestamp":1706833941000},"page":"3046-3067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Oridonin from\n                    <i>Rabdosia rubescens<\/i>\n                    : An emerging potential in cancer therapy \u2013 A comprehensive review"],"prefix":"10.1002","volume":"12","author":[{"given":"Muhammad Asif","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Food Science and Human Nutrition UVAS  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noohela","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences Rashid Latif Medical College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition UVAS  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition UVAS  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushaba","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition UVAS  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinza","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition UVAS  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooba","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Healthcare Biotechnology, Atta\u2010ur\u2010Rahman School of Applied Biosciences National University of Sciences and Technology  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushbukhat","family":"Khan","sequence":"additional","affiliation":[{"name":"Cancer Clinical Research Unit, Trials360  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Armaghan","sequence":"additional","affiliation":[{"name":"Department of Healthcare Biotechnology, Atta\u2010ur\u2010Rahman School of Applied Biosciences National University of Sciences and Technology  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Palma\u2010Morales","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Facultad de Farmacia Universidad de Granada  Granada Spain"},{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos \u2018Jos\u00e9 Mataix\u2019 Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Rodr\u00edguez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Facultad de Farmacia Universidad de Granada  Granada Spain"},{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos \u2018Jos\u00e9 Mataix\u2019 Universidad de Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (ibs.GRANADA)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Caunii","sequence":"additional","affiliation":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-5000","authenticated-orcid":false,"given":"Monica","family":"Butnariu","sequence":"additional","affiliation":[{"name":"University of Life Sciences \"King Mihai I\" from Timisoara  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Habtemariam","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research &amp; 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