{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:08:09Z","timestamp":1790010489507,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Allium species are consumed extensively as folkloric medicine and dietary elements, but limited studies have been conducted on them. In this study, the effects of an ethanol\u2013water extract obtained from the underground bulb of\n                    <jats:italic>Allium tuncelianum<\/jats:italic>\n                    (Kollmann) \u00d6zhatay, B. Mathew &amp; \u015eiraneci (AT) on the behavioral, antioxidant, and metabolite parameters in rats were evaluated. AT was administered orally once a day at doses of 100 and 400\u2009mg\/kg to male Wistar albino rats for 10 consecutive days. The elevated plus maze, rotarod, and hotplate tests were used to examine anxiety\u2010like behaviors, locomotor activities, and pain perception in the rats, respectively. Additionally, untargeted metabolomic analyses were performed on plasma samples and AT extracts using two orthogonal analytical platforms. The phenolic components, mainly fumaric acid, malic acid, vanillic acid, quercetin\u20103\u2010arabinoside, hydrocinnamic acid, and gallocatechin, were determined in the extract. In addition, arbutin, salicylic acid, trehalose, and nicotinic acid were analyzed in the extract for the first time. The AT extract did not decrease the catalase, glutathione peroxidase, or superoxide dismutase levels; however, diazepam decreased some of those parameters significantly in the brain, liver, and kidney. Although both the AT and diazepam treatments resulted in an increase in anxiolytic\u2010like effects compared to the control group, no significant differences were observed (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). In the metabolomic analysis, significant changes were observed in the rats treated with AT and diazepam, and they caused significant changes in some metabolic pathways, including amino acid and fatty acid metabolism, compared to the control.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4022","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T10:28:24Z","timestamp":1708597704000},"page":"3538-3551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Behavior, antioxidant, and metabolomics effects of\n                    <i>Allium tuncelianum<\/i>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8015-1541","authenticated-orcid":false,"given":"Nigar","family":"Abbak","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-6215","authenticated-orcid":false,"given":"Emirhan","family":"Nemutlu","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Re\u00e7ber","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli San Dagli","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-8003","authenticated-orcid":false,"given":"H. Turan","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Department of Physiology, Veterinary Faculty Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahire Bayramoglu","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Veterinary Faculty Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulderen","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-5028","authenticated-orcid":false,"given":"Suat","family":"Ekin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Arihan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.03.046"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.06.020"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.31989\/ffhd.v2i11.71"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2023.106547"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.33988\/auvfd.430457"},{"issue":"1","key":"e_1_2_13_8_1","first-page":"212","article-title":"Hypoglycaemic activity of different extracts of various herbal plants","volume":"1","author":"Ayodhya S.","year":"2010","journal-title":"International Journal of Research in Ayurveda and Pharmacy (IJRAP)"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13931"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/bbandelow"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12101124"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.026"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.18203\/2319\u20102003.ijbcp20164094"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12928"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030872"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2021.1982297"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.06.022"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.10.038"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22\u201005\u201001592.2002"},{"key":"e_1_2_13_21_1","unstructured":"Fritsch R. 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