{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:21Z","timestamp":1786977741525,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["23162"],"award-info":[{"award-number":["23162"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Curcumin is known for its antioxidant properties. This study aimed to investigate the impact of curcumin on acrylamide (ACR)\u2010induced alterations in the first\u2010line antioxidant defense of ovarian tissue. Female Balb\/c mice were divided into control, ACR (50\u2009mg\/kg), ACR\/CUR100 (received Acr\u2009+\u2009curcumin100\u2009mg\/kg), and ACR\/CUR200 (Acr\u2009+\u2009curcumin 200\u2009mg\/kg) groups, and received oral treatments for 35\u2009days. Evaluation of antioxidant enzyme expression (\n                    <jats:italic>Sod<\/jats:italic>\n                    ,\n                    <jats:italic>Cat<\/jats:italic>\n                    ,\n                    <jats:italic>Gpx<\/jats:italic>\n                    genes), pro\u2010apoptotic gene expressions (\n                    <jats:italic>Bax<\/jats:italic>\n                    ,\n                    <jats:italic>Caspase 3<\/jats:italic>\n                    ), and anti\u2010apoptotic gene expression (\n                    <jats:italic>Bcl2l1<\/jats:italic>\n                    ) at mRNA and protein levels was done. Percentage of apoptotic cells using Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was performed. The model group (ACR) showed decreased mRNA expression of\n                    <jats:italic>Sod<\/jats:italic>\n                    ,\n                    <jats:italic>Cat<\/jats:italic>\n                    , and\n                    <jats:italic>Gpx<\/jats:italic>\n                    genes compared with the control group. Treatment with two different doses of curcumin (CUR100 and CUR200) significantly increased\n                    <jats:italic>Sod<\/jats:italic>\n                    ,\n                    <jats:italic>Cat<\/jats:italic>\n                    , and\n                    <jats:italic>Gpx<\/jats:italic>\n                    gene expression, with CUR200 demonstrating significant recovery. SOD, CAT, and GPX protein levels were similar to mRNA expression trends, significantly increased with curcumin administration. Acrylamide exposure significantly increased\n                    <jats:italic>Bax<\/jats:italic>\n                    and\n                    <jats:italic>Caspase 3<\/jats:italic>\n                    expression and decreased\n                    <jats:italic>Bcl2l1<\/jats:italic>\n                    gene expression leading to a notable rise in apoptosis in ACR group as compared to the control group. Conversely, curcumin administration, significantly reduced\n                    <jats:italic>Bax<\/jats:italic>\n                    and\n                    <jats:italic>Caspase 3<\/jats:italic>\n                    expressions, with an increase in\n                    <jats:italic>Bcl2l1expression<\/jats:italic>\n                    , though not statistically significant. TUNEL assay revealed a substantial decrease in apoptosis in curcumin\u2010received groups. In our study, ACR exposure adversely affected ovarian antioxidant defense thereby leading to increased pro\u2010apoptotic markers. Notably, curcumin treatment effectively mitigated these effects, restored antioxidant potential, and reduced acrylamide\u2010induced toxicity in female mouse ovaries.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4076","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:19:54Z","timestamp":1709857194000},"page":"4160-4172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Curcumin mitigates acrylamide\u2010induced ovarian antioxidant disruption and apoptosis in female Balb\/c mice: A comprehensive study on gene and protein expressions"],"prefix":"10.1002","volume":"12","author":[{"given":"Sanaz","family":"Alaee","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Stem Cells Technology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Khodabandeh","sequence":"additional","affiliation":[{"name":"Stem Cells Technology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahintaj","family":"Dara","sequence":"additional","affiliation":[{"name":"Stem Cells Technology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-6262","authenticated-orcid":false,"given":"Elham","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mousavi Hospital, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"},{"name":"Zanjan Metabolic Diseases Research Center Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology AIIMS  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.958"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110595"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjr.2015.05.001"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD18472"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3818"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2020.6167"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14219"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3248"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2787"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000629\u20104"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156144"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11562"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2790"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejchem.2022.139554.6136"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.515"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2023.100705"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6339715"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2022.07.015"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3101"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010023\u201001295\u20105"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2017.05.004"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201013\u20100509"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v21i1.12668"},{"key":"e_1_2_12_25_1","first-page":"292","article-title":"Protective role of polyphenols (anthocyanin, gallic acid) and blackberry juice against acrylamide reproductive toxicity in male rats","volume":"23","author":"Ibrahim A. 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