{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:26:13Z","timestamp":1790659573028,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the changes of people's lifestyle, hyperlipidemia and hyperglycemia which were induced from a diet high in both fat and sugar have become serious health concerns. Tree peony seed oil (PSO) is a novel kind of edible oil that shows great potential in the food industry because of its high constituent of unsaturated fatty acids. Based 16S rRNA and gut untargeted metabolomics, this study elucidated that the mechanism of PSO regulating blood glucose (Glu) and lipids. The impact of PSO on gut microbiota balance and gut metabolites of mice with a high\u2010fat diet (HFD) was evaluated. The findings indicated that PSO decreased HFD mice's body weight and fat accumulation, ameliorating the levels of blood lipid, reduced liver fat vacuole levels. What's more PSO modulated the proportion of gut microbiota in HFD mice and enhanced the abundance of probiotics. Furthermore, untargeted metabolomic analysis revealed that PSO not only impacted the generation of short\u2010chain fatty acids (SCFAs) by gut microorganism and altered metabolic pathway but exerted influence on secondary bile acids (BA), amino acid metabolism, and various other metabolites. These results suggested that PSO has the potential function for mitigating HFD\u2010induced hyperlipidemia and hyperglycemia by regulating gut microbiota and host metabolism.<\/jats:p>","DOI":"10.1002\/fsn3.4108","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T07:46:36Z","timestamp":1712216796000},"page":"4421-4434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tree peony seed oil alleviates hyperlipidemia and hyperglycemia by modulating gut microbiota and metabolites in high\u2010fat diet mice"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0617-5111","authenticated-orcid":false,"given":"Ziyue","family":"Liang","sequence":"first","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2634-7342","authenticated-orcid":false,"given":"Yinglong","family":"He","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6675-4592","authenticated-orcid":false,"given":"Dongfeng","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Urban Construction, Luoyang Vocational and Technical College  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1639-5735","authenticated-orcid":false,"given":"Peixin","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-7422","authenticated-orcid":false,"given":"Yuying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3091-0947","authenticated-orcid":false,"given":"Di","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-7795","authenticated-orcid":false,"given":"Xiaogai","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Agriculture\/Tree Peony Henan University of Science and Technology  Luoyang China"},{"name":"Key Laboratory of Efficient Cultivation and Comprehensive Utilization of Tree Peony in Henan Province  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03155-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134598"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.128444"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-018-0275-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1203932"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.10.387"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz198"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0560-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.038"},{"key":"e_1_2_10_13_1","first-page":"1286","article-title":"Experimental study on hypolipidemic and hypoglycemic effects of peony seed oil","volume":"17","author":"Dong Z. X.","year":"2013","journal-title":"Anhui Medical and Pharmaceutical Journal"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47289"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804024-9.00031-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01443-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051128"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO04094A"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904099116"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.210"},{"key":"e_1_2_10_21_1","first-page":"569","article-title":"Advances in study on intestinal microecology and metabolic disease","volume":"18","author":"Jia L.","year":"2013","journal-title":"Chinese Journal of Gastroenterology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00804-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MA0821-639RR"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00785-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122424"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.015"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02785-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01195-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcms.2020.04.006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess20206"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030593"},{"key":"e_1_2_10_32_1","first-page":"1548","article-title":"The role of gut microbiota in mediating obesity and diabetes mellitus","volume":"24","author":"Pitocco D.","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324053"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13252"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519001399"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.109275"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3318"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820602-7.00008-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.028"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2022.2073367"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03412J"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00885"},{"key":"e_1_2_10_43_1","first-page":"26","article-title":"Effects of ethanol extract of Clinacanthus nutans on gut microbiota and lipid metabolism of HFD\u2010induced obese mice","volume":"13","author":"Yang J.","year":"2022","journal-title":"Medicinal Plants"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.16246"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16568-z"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235985"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.025"},{"key":"e_1_2_10_48_1","first-page":"2602","article-title":"The clinical effect of Peony seed oil in the treatment of hypertension complicated with hyperlipidemia and its improvement on blood lipid level","volume":"34","author":"Yuan H.","year":"2019","journal-title":"Guangming Journal of Chinese Medicine"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023039"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15790"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900638"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3136"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO00638C"},{"key":"e_1_2_10_54_1","article-title":"Hypolipidemic and antioxidant activities of Trichosanthes kirilowii maxim seed oil and flavonoids in mice fed with a high\u2010fat diet","volume":"44","author":"Zong H.","year":"2020","journal-title":"Journal of Food Biochemistry"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T07:14:06Z","timestamp":1718176446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/fsn3.4108"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4108","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"2023-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}